基于干细胞衍生细胞外囊泡的神经损伤治疗：分子机制综述
Stem cell-derived extracellular vesicle-based therapy for nerve injury: A review of the molecular mechanisms.
作者信息
Nasiry Davood, Khalatbary Ali Reza
机构信息
Amol Faculty of Paramedicine, Mazandaran University of Medical Sciences, Sari, Iran.
Cellular and Molecular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
World Neurosurg X. 2023 Apr 25;19:100201. doi: 10.1016/j.wnsx.2023.100201. eCollection 2023 Jul.
Abstract
Recent evidence suggests that stem cell therapy has beneficial effects on nerve damage. These beneficial effects were subsequently found to be exerted in part in a paracrine manner by the release of extracellular vesicles. Stem cell-secreted extracellular vesicles have shown great potential to reduce inflammation and apoptosis, optimize the function of Schwann cells, regulate genes related to regeneration, and improve behavioral performance after nerve damage. This review summarizes the current knowledge on the effect of stem cell-derived extracellular vesicles on neuroprotection and regeneration along with their molecular mechanisms after nerve damage.
摘要
近期证据表明，干细胞疗法对神经损伤具有有益作用。随后发现，这些有益作用部分是通过细胞外囊泡的释放以旁分泌方式发挥的。干细胞分泌的细胞外囊泡在减轻炎症和细胞凋亡、优化施万细胞功能、调节与再生相关的基因以及改善神经损伤后的行为表现方面显示出巨大潜力。本文综述了目前关于干细胞来源的细胞外囊泡在神经损伤后对神经保护和再生的作用及其分子机制的知识。
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