Hooda Reet, Madke Bhushan, Choudhary Ankita
Dermatology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Wardha, IND.
Dermatology, Venereology, and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Wardha, IND.
Cureus. 2023 Apr 9;15(4):e37321. doi: 10.7759/cureus.37321. eCollection 2023 Apr.
Redox flagging represents all life processes, and maintaining a physiological level of antioxidants is essential for the legitimate working of the cell. Genetics and environmental triggers are two major culminating factors for skin aging, both chronological and photoaging. The latter, however, relies principally upon the level of ultraviolet radiation (UVR) exposure and the skin phototype. Apart from causing DNA damage, UVR also stimulates the receptors present in keratinocytes as well as fibroblasts. This in turn leads to the breakdown of collagen and a breach in the generation of new collagen. It is speculated that the breakdown of collagen in the dermis is ensured by the defective restoration that ultimately hampers the structural integrity of skin, leading to wrinkled and atrophic skin. The skin has an admixture of various endogenous antioxidants that work synergistically with vitamins and minerals to maintain cellular equilibrium. Although, their role in safeguarding the cells against the detrimental effects induced by UVR is still questionable and requires further research. However, the advancement in the biology of skin has led to the development of strategies that aim at skin rejuvenation and retarding the progression of photoaging and its visible signs. Photoaging in this article is reviewed in light of current concepts in pathogenesis and its prevention. In addition, the article focuses on both prevailing and forthcoming treatment strategies primarily through plant-based products that will help slow down the process of photoaging.
氧化还原标记代表了所有生命过程，维持生理水平的抗氧化剂对于细胞的正常运作至关重要。遗传因素和环境诱因是皮肤老化（包括自然老化和光老化）的两个主要最终因素。然而，后者主要取决于紫外线辐射（UVR）暴露水平和皮肤光类型。除了导致DNA损伤外，UVR还会刺激角质形成细胞和成纤维细胞中存在的受体。这进而导致胶原蛋白分解以及新胶原蛋白生成的中断。据推测，真皮中胶原蛋白的分解是由修复缺陷导致的，最终会阻碍皮肤的结构完整性，导致皮肤出现皱纹和萎缩。皮肤含有多种内源性抗氧化剂，它们与维生素和矿物质协同作用以维持细胞平衡。尽管如此，它们在保护细胞免受UVR诱导的有害影响方面的作用仍存在疑问，需要进一步研究。然而，皮肤生物学的进展已导致旨在实现皮肤年轻化并延缓光老化进程及其可见迹象的策略的发展。本文将根据当前发病机制及其预防的概念对光老化进行综述。此外，本文主要通过植物性产品重点介绍当前和未来的治疗策略，这些策略将有助于减缓光老化进程。
