Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Pediatr Rehabil Med. 2023;16(2):391-400. doi: 10.3233/PRM-220054.
Acute flaccid myelitis (AFM), an uncommon but serious neurologic condition, primarily affects children, and can progress quickly to paralysis and respiratory failure. Data on long-term outcomes of patients with AFM are limited. This study reports on functional status through 12 months for AFM patients who became ill in 2018 in the United States.
Health departments collected information on outcomes at 6 and 12 months after onset of AFM using a standardized form that asked patients or their parents/guardians about functional status. Analyses were restricted to confirmed cases.
Of the 238 confirmed AFM cases reported to CDC in 2018, 90 (38%) had assessments at 6 months, 82 (34%) at 12 months, and 49 (21%) at both 6 and 12 months. Among the 49 patients with data at both time points, the proportion of patients reporting significant or severe impairment at 6 months ranged from 2% to 59% depending on the outcome. Although proportions decreased by 12 months and ranged from 2% to 51%, most patients had some impairment at 12 months. No deaths were reported.
Six- and 12-month outcomes in patients with onset of AFM in 2018 span a wide range of functionality, particularly of upper and lower extremities. Importantly, improvement appears to occur over time in some patients.
急性弛缓性脊髓炎（AFM）是一种罕见但严重的神经系统疾病，主要影响儿童，可迅速进展为瘫痪和呼吸衰竭。关于 AFM 患者长期结局的数据有限。本研究报告了 2018 年在美国发病的 AFM 患者 12 个月的功能状态。
卫生部门使用标准化表格收集发病后 6 个月和 12 个月时的结局信息，询问患者或其父母/监护人的功能状态。分析仅限于确诊病例。
2018 年向 CDC 报告的 238 例确诊 AFM 病例中，90 例（38%）在发病后 6 个月进行了评估，82 例（34%）在 12 个月进行了评估，49 例（21%）在 6 个月和 12 个月都进行了评估。在这 49 例同时有两个时间点数据的患者中，根据不同的结局，报告 6 个月时存在显著或严重功能障碍的患者比例在 2%至 59%之间。尽管到 12 个月时比例下降，范围在 2%至 51%之间，但大多数患者在 12 个月时仍存在某种程度的功能障碍。没有死亡报告。
2018 年发病的 AFM 患者的 6 个月和 12 个月结局的功能状态范围很广，特别是上肢和下肢。重要的是，一些患者的情况似乎随着时间的推移而有所改善。
