Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA.
Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA.
Surg Oncol Clin N Am. 2023 Jul;32(3):415-432. doi: 10.1016/j.soc.2023.02.002. Epub 2023 Apr 4.
During the past 30 years, several advances have been made allowing for safer and more effective treatment of patients with liver cancer. This report reviews recent advances in radiation therapy for primary liver cancers including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. First, studies focusing on liver stereotactic body radiation therapy (SBRT) are reviewed focusing on lessons learned and knowledge gained from early pioneering trials. Then, new technologies to enhance SBRT treatments are explored including adaptive therapy and MRI-guided and biology-guided radiation therapy. Finally, treatment with Y-90 transarterial radioembolization is reviewed with a focus on novel approaches focused on personalized therapy.
在过去的 30 年中，已经取得了一些进展，使得治疗肝癌患者的安全性和有效性得到提高。本报告回顾了原发性肝癌（包括肝细胞癌和肝内胆管细胞癌）放射治疗的最新进展。首先，回顾了重点关注从早期开拓性试验中获得的经验教训和知识的肝脏立体定向体部放射治疗（SBRT）研究。然后，探讨了增强 SBRT 治疗的新技术，包括适应性治疗以及 MRI 引导和生物学引导的放射治疗。最后，回顾了 Y-90 经动脉放射性栓塞治疗，重点介绍了专注于个性化治疗的新方法。
