严重神经精神障碍患者的行为心理症状群模式：来自 RECAGE 研究的见解。
BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study.
机构信息
Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France.
Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Université Paris Cité (SS, JD), Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.
出版信息
Am J Geriatr Psychiatry. 2023 Aug;31(8):633-639. doi: 10.1016/j.jagp.2023.03.014. Epub 2023 Apr 23.
OBJECTIVE
Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD.
METHODS
We analyzed data collected at baseline in 398 patients with severe BPSD (NPI ≥ 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE.
RESULTS
Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms.
CONCLUSION
Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.
目的
轻度至中度行为和心理症状的痴呆症（BPSD）的表现因病因而异。目前尚不清楚严重 BPSD 患者是否存在类似的差异。
方法
我们分析了 398 名严重 BPSD 患者（NPI≥32）基线时收集的数据，并定义了包括在欧洲多中心队列 RECAGE 中的痴呆症诊断（阿尔茨海默病[AD]297；额颞叶痴呆[FTD]39；路易体病/帕金森病痴呆[LBD/PD]31；血管性痴呆[VD]31）。
结果
平均总 NPI 为 52.11（18.55）。与其他痴呆症患者相比，LBD/PD 患者表现出更多的幻觉、更多的焦虑和更多的妄想。与其他神经退行性疾病患者相比，FTD 患者的妄想较少，而脱抑制较多。这些表型与文献中报道的轻度症状患者的表型部分重叠。
结论
严重 BPSD 患者根据痴呆症病因表现出不同且特定的神经精神症状特征。
Zotero 插件