Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy.
Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
J Oral Rehabil. 2023 Sep;50(9):877-885. doi: 10.1111/joor.13496. Epub 2023 May 24.
While Temporomandibular disorders (TMDs) are not typically considered a primary symptom of Parkinson disease (PD), recent studies have documented a correlation between ageing and TMDs, a cluster of conditions affecting the temporomandibular joint and surrounding musculature, thereby underscoring the potential for an increased frequency of TMDs in the ageing PD population.
The purpose of this review is to systematically evaluate the existing literature on the topic and provide a comprehensive overview of the prevalence of TMDs in patients with PD.
To determine eligibility, we utilised the Population (human subjects), Exposure (PD), Comparator (PD vs non-PD subjects), and Outcomes (TMD) (PECO) model. To conduct this systematic review, we searched for articles published in PubMed, Web of Science and Lilacs from the beginning until April 15, 2023.
Three studies were selected. All together they comprised a total of 55 828 subjects, out of which 12 629 were affected by PD or Parkinsonism, and the remaining 43 199 were non-PD subjects matched for age and sex. The study aimed to evaluate the prevalence of TMDs in subjects affected by PD. The results showed that 193/12629 (1.53%) of PD individuals presented with TMD symptoms or were diagnosed with TMD, while 260/43199 (0.6%) of non-PD subjects were diagnosed with the same. The meta-analysis showed that there was a higher TMD prevalence in PD subjects compared to non-PD subjects (RR 1.57; 95% CI: 1.30-1.89).
The studies reviewed suggest a possible association between TMD and PD. Further research is needed to clarify the relationship between TMD and PD and to identify possible mechanisms and treatment strategies.
虽然颞下颌关节紊乱症（TMD）通常不被认为是帕金森病（PD）的主要症状，但最近的研究记录了衰老与 TMD 之间的相关性，TMD 是一组影响颞下颌关节及其周围肌肉的疾病，从而强调了 TMD 在老年 PD 人群中发生率增加的可能性。
本综述的目的是系统评估现有关于该主题的文献，并提供 PD 患者 TMD 患病率的全面概述。
为了确定纳入标准，我们使用了人群（人体受试者）、暴露（PD）、对照（PD 与非 PD 受试者）和结局（TMD）（PECO）模型。为了进行这项系统综述，我们在 PubMed、Web of Science 和 Lilacs 中搜索了从开始到 2023 年 4 月 15 日发表的文章。
选择了三项研究。这三项研究共包括 55828 名受试者，其中 12629 名患有 PD 或帕金森病，其余 43199 名是年龄和性别匹配的非 PD 受试者。这项研究旨在评估 PD 患者中 TMD 的患病率。结果表明，193/12629（1.53%）名 PD 患者出现 TMD 症状或被诊断为 TMD，而 260/43199（0.6%）名非 PD 患者被诊断为 TMD。荟萃分析表明，PD 患者的 TMD 患病率高于非 PD 患者（RR 1.57；95%CI：1.30-1.89）。
综述中的研究表明 TMD 与 PD 之间可能存在关联。需要进一步的研究来阐明 TMD 和 PD 之间的关系，并确定可能的机制和治疗策略。
