Etablissement Français du Sang, La Plaine Saint-Denis, France.
UMR RIGHT 1098 Inserm, Université de Franche-Comté, Etablissement Français du Sang, Besançon, France.
Vox Sang. 2023 Jun;118(6):440-446. doi: 10.1111/vox.13435. Epub 2023 May 14.
Since the advent of AIDS, men who have sex with men (MSM) have often been deferred from blood donation. In France, quarantine plasma donation by MSM donors with the same deferral rules as for other donors was introduced in July 2016 and continued up to March 2022. At this time, MSM-specific deferral criteria were lifted for all blood or plasma donation. The donor deferral, as well as rate of infectious markers in plasma donors who would have been otherwise deferred for MSM activity, was evaluated and compared with those of the other donors during the same time period from June 2016 to March 2022.
A total of 8843 MSM donors made 12,250 plasma donation applications. The overall deferral rate was very high (75.2%), mainly due to the absence of apheresis capacity at the donation site. The deferral criteria for sexual risk were present in 12.1% of MSM donors compared with 1.0% in other plasma and blood donors (p < 0.001). Overall, 994 MSM donors made 2880 plasma donations. Of these, one donation was HIV positive (34.7 vs. 0.6/10 donations by other donors, relative risk [RR]: 61.0 [95% confidence interval [CI]: 8.5-437.7]), one was HBV positive (34.7 vs. 4.5/10 , RR: 7.7 [95% CI: 1.1-54.6]) and none were HCV positive (0 vs. 2.4/10 ). Additionally, 21 donations were syphilis positive (729.2 vs. 10.7/10 , RR: 67.9 [95% CI: 44.2-104.4]). A post hoc analysis of eligible MSM donors who were unable to donate plasma due to logistic constraints yielded similar findings.
Plasma donation by donors who would have been otherwise deferred for MSM activity was associated with both an increased deferral rate for sexual risk and an increased rate of infectious markers, notably syphilis.
自艾滋病出现以来，男男性行为者（MSM）经常被推迟献血。在法国，自 2016 年 7 月起，按照与其他供者相同的延期规则，对 MSM 供者进行检疫血浆捐献，并持续至 2022 年 3 月。此时，解除了所有血液或血浆捐献中针对 MSM 活动的特定延期标准。评估并比较了 2016 年 6 月至 2022 年 3 月期间，因 MSM 活动而本应被延期的供者的献血延期率和血浆供者的感染标志物发生率。
共有 8843 名 MSM 供者进行了 12250 次血浆捐献申请。整体延期率非常高（75.2%），主要原因是献血点缺乏单采能力。在 MSM 供者中，与性风险相关的延期标准存在于 12.1%的供者中，而在其他血浆和血液供者中仅为 1.0%（p<0.001）。总体而言，994 名 MSM 供者进行了 2880 次血浆捐献。其中，1 份捐献物 HIV 阳性（34.7 比其他供者的 0.6/10 份，相对风险 [RR]：61.0 [95%置信区间 [CI]：8.5-437.7]），1 份 HBV 阳性（34.7 比其他供者的 4.5/10 份，RR：7.7 [95% CI：1.1-54.6]），无 HCV 阳性（0 比其他供者的 2.4/10 份）。此外，21 份捐献物梅毒阳性（729.2 比其他供者的 10.7/10 份，RR：67.9 [95% CI：44.2-104.4]）。对因物流限制而无法捐献血浆的合格 MSM 供者进行的事后分析得出了类似的结果。
因 MSM 活动而被推迟的供者进行血浆捐献，与性风险的延期率增加和感染标志物（尤其是梅毒）的增加率相关。
