Wu Yang, Zhao Jing, Wang Mengzhao
School of Medicine, Tsinghua University, Beijing 100084, China.
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhongguo Fei Ai Za Zhi. 2023 Apr 20;26(4):303-309. doi: 10.3779/j.issn.1009-3419.2023.106.08.
Small cell lung cancer (SCLC) is a malignant tumor with remarkable proliferative and invasive ability, which has very poor clinical prognosis due to lack of effective treatments. In recent years, researches on cells, animal models and tumor samples have promoted the identification of molecular subtypes of SCLC, discovered unique biological and clinical characteristics, and proposed potential specific therapeutic targets for different subtypes. This will encourage the development of more accurate therapeutic strategies towards SCLC, with a view to improving the prognosis of the patients. This article will review the current SCLC molecular subtypes, focus on the clinical characteristics and therapeutic strategies of different SCLC subtypes, and propose reasonable suggestions for the future treatment of SCLC. .
小细胞肺癌（SCLC）是一种具有显著增殖和侵袭能力的恶性肿瘤，由于缺乏有效的治疗方法，其临床预后非常差。近年来，对细胞、动物模型和肿瘤样本的研究推动了SCLC分子亚型的鉴定，发现了独特的生物学和临床特征，并提出了针对不同亚型的潜在特异性治疗靶点。这将促进针对SCLC的更精确治疗策略的发展，以期改善患者的预后。本文将综述当前SCLC的分子亚型，重点关注不同SCLC亚型的临床特征和治疗策略，并对SCLC的未来治疗提出合理建议。
