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High Dose Dexamethasone in Complicated Typhoid Fever: What is the Evidence?

作者信息

Nain Zulquar

机构信息

Department of Pediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India.

出版信息

Indian J Pediatr. 2023 Nov;90(11):1162. doi: 10.1007/s12098-023-04666-x. Epub 2023 May 15.

DOI:10.1007/s12098-023-04666-x
PMID:37184716
Abstract
摘要

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Typhoid toxin causes neuropathology by disrupting the blood-brain barrier.伤寒毒素通过破坏血脑屏障导致神经病理学变化。
Nat Microbiol. 2025 May 8. doi: 10.1038/s41564-025-02000-z.

本文引用的文献

1
Factors associated with encephalopathy in patients with Salmonella enterica serotype Typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh.孟加拉国达卡一家腹泻医院收治的伤寒沙门氏菌菌血症患者发生脑病的相关因素。
Am J Trop Med Hyg. 2012 Apr;86(4):698-702. doi: 10.4269/ajtmh.2012.11-0750.
2
Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone.大剂量地塞米松降低氯霉素治疗的重症伤寒热死亡率。
N Engl J Med. 1984 Jan 12;310(2):82-8. doi: 10.1056/NEJM198401123100203.
3
Treatment of severe typhoid fever in children with high dose dexamethasone.
大剂量地塞米松治疗儿童重症伤寒热。
Pediatr Infect Dis J. 1988 Aug;7(8):598-600. doi: 10.1097/00006454-198808000-00002.