Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200235, P. R. China.
Adv Healthc Mater. 2023 Sep;12(22):e2300163. doi: 10.1002/adhm.202300163. Epub 2023 May 25.
As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase-like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)-scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs' therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.
作为最广泛使用的药物之一，对乙酰氨基酚是急性肝损伤的主要原因。此外，对乙酰氨基酚诱导的肝损伤（AILI）与过量产生的活性氧（ROS）密切相关，纳米酶可以有效清除这些 ROS。为了解决这些挑战，合成了模拟过氧化物酶、过氧化氢酶和超氧化物歧化酶特性的介孔 PdPt@MnO 纳米探针（PPM NPs）。它们表现出无毒、高胶体稳定性和出色的活性氧（ROS）清除能力。通过清除过量的 ROS、减少炎症细胞因子、抑制单核细胞/巨噬细胞和中性粒细胞的募集和激活，证实了 PPM NPs 在 AILI 中的病理机制。此外，PPM NPs 的治疗效果和良好的生物相容性可能有助于 AILI 的临床治疗。
