Güttler K, Jenke J, Klaus W
Arzneimittelforschung. 1986 Apr;36(4):684-8.
The antagonistic effect of triamterene on the toxicity of cardiac glycosides was investigated in conscious rabbits using the infusion method. Pretreatment with triamterene (5 mg/kg and 10 mg/kg) significantly reduces the ouabain toxicity indicated by an increase of the dose producing arrhythmia (from 61 +/- 14 to 121 +/- 17 and 178 +/- 22 micrograms/kg, resp.) and lethality (from 114 +/- 18 to 236 +/- 5 and 329 +/- 11 micrograms/kg, resp.). The triamterene induced increase of plasma potassium concentration may contribute to the antitoxic effect, however, the effect persisted after the decrease of plasma potassium concentration (by addition of NaHCO3) to pretreatment values. Under the influence of digitoxin the antitoxic effect of triamterene (10 mg/kg) is also demonstrated by the delayed appearance of arrhythmias (113 +/- 3 min compared to 78 +/- 5 min) and of lethality (125 +/- 4 min compared to 92 +/- 6 min). Triamterene is not only a prophylactic but also a curative antitoxic agent in the digitalis intoxicated rabbit.
采用输注法在清醒家兔身上研究了氨苯蝶啶对强心苷毒性的拮抗作用。用氨苯蝶啶（5毫克/千克和10毫克/千克）预处理可显著降低哇巴因毒性，表现为产生心律失常的剂量增加（分别从61±14微克/千克增至121±17微克/千克和178±22微克/千克）以及致死率增加（分别从114±18微克/千克增至236±5微克/千克和329±11微克/千克）。氨苯蝶啶诱导的血浆钾浓度升高可能有助于其抗毒作用，然而，在血浆钾浓度（通过添加碳酸氢钠）降至预处理值后，该作用仍持续存在。在洋地黄毒苷的影响下，氨苯蝶啶（10毫克/千克）的抗毒作用还表现为心律失常出现延迟（分别为113±3分钟和78±5分钟）以及致死出现延迟（分别为125±4分钟和92±6分钟）。在洋地黄中毒的家兔中，氨苯蝶啶不仅是一种预防性抗毒药，也是一种治疗性抗毒药。
