关于双氢睾酮对男性促黄体生成激素释放激素诱导的促性腺激素释放影响的进一步研究。

Further studies on the effects of dihydrotestosterone on gonadotrophin release induced by LH-RH in men.

作者信息

Andò S, Polosa P, D'Agata R

出版信息

Clin Endocrinol (Oxf). 1978 Dec;9(6):557-62. doi: 10.1111/j.1365-2265.1978.tb01514.x.

DOI:10.1111/j.1365-2265.1978.tb01514.x

Abstract

In order to determine the effect of dihydrotestosterone on the feed-back mechanism of the hypothalamo-pituitary testis axis, seven men were subjected to LH-RH tests before and after treatment with dihydrotestosterone. Our results clearly show that DHT at least in pharmacological doses, inhibits directly basal LH-RH and gonadotrophin secretion, without affecting the pulsatile gonadotrophin release or impairing the pituitary response to LH-RH. The physiological significance of these observations remains however to be proven.

摘要

为了确定双氢睾酮对下丘脑 - 垂体 - 睾丸轴反馈机制的影响，对7名男性在接受双氢睾酮治疗前后进行了促黄体生成素释放激素（LH - RH）测试。我们的结果清楚地表明，至少在药理剂量下，双氢睾酮直接抑制基础LH - RH和促性腺激素的分泌，而不影响促性腺激素的脉冲式释放，也不损害垂体对LH - RH的反应。然而，这些观察结果的生理学意义仍有待证实。