National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, Australia.
Centre for Big Data Research in Health, UNSW Sydney, Sydney, Australia.
Drug Alcohol Rev. 2023 Sep;42(6):1461-1471. doi: 10.1111/dar.13669. Epub 2023 Apr 25.
For people accessing treatment for problems with drugs other than opioids, little is known about the relationship between treatment and mortality risk, nor how mortality risk varies across treatment modalities. We addressed these evidence gaps by determining mortality rates during and after treatment for people accessing a range of treatment modalities for several drugs of concern.
We conducted a cohort study using linked data on publicly funded specialist alcohol or other drug treatment service use and mortality for people receiving treatment in New South Wales between January 2012 and December 2018. We calculated and compared during-treatment and post-treatment crude mortality rates and age- and sex-standardised mortality rates, separately for each principal drug of concern and modality.
Over the study period, 45,026 people accessed treatment for problems with alcohol, 26,407 for amphetamine-type stimulants, 23,047 for cannabinoids and 21,556 for opioids. People treated for alcohol or opioid problems had higher crude mortality rates (1.48, 1.91, 1.09 per 100 person years, respectively) than those with problems with amphetamine-type stimulants or cannabinoids (0.46, 0.30 per 100 person years, respectively). Mortality rates differed according to treatment status and modality only among people with alcohol or opioid problems.
The observed variation in mortality rates indicates there is scope to reduce mortality among people accessing treatment with alcohol or opioid problems. Future research on mortality among people accessing drug and alcohol treatment should account for the variation in mortality by drug of concern and treatment modality.
对于因除阿片类药物以外的其他药物而接受治疗的人来说,人们对治疗与死亡风险之间的关系知之甚少,也不知道治疗方式如何影响死亡风险。我们通过确定因各种药物滥用问题接受一系列治疗方式的人在治疗期间和治疗后的死亡率,来填补这些证据空白。
我们使用新南威尔士州在 2012 年 1 月至 2018 年 12 月期间接受公共资助的酒精或其他药物治疗服务的使用情况和死亡率的相关数据,开展了一项队列研究。我们分别针对每个主要关注药物和治疗方式,计算和比较了治疗期间和治疗后的粗死亡率以及年龄和性别标准化死亡率。
在研究期间,有 45026 人因酒精问题接受治疗,26407 人因安非他命类兴奋剂问题接受治疗,23047 人因大麻素问题接受治疗,21556 人因阿片类药物问题接受治疗。治疗酒精或阿片类药物问题的患者粗死亡率(分别为每 100 人年 1.48、1.91 和 1.09)高于治疗安非他命类兴奋剂或大麻素问题的患者(分别为每 100 人年 0.46 和 0.30)。只有酒精或阿片类药物问题患者的治疗状况和方式会影响死亡率。
观察到的死亡率差异表明,有降低接受酒精或阿片类药物问题治疗的患者死亡率的空间。未来针对药物和酒精治疗患者死亡率的研究应该考虑到关注药物和治疗方式对死亡率的影响。