Pfizer, Inc., Groton, Connecticut.
Pfizer, Global Medical Affairs, Paris, France.
J Glob Antimicrob Resist. 2023 Jun;33:360-367. doi: 10.1016/j.jgar.2023.05.002. Epub 2023 May 13.
Ceftaroline is an important therapeutic option for community-acquired pneumonia (CAP). Antimicrobial susceptibility to ceftaroline and other antimicrobial agents against Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae isolates collected worldwide from identified respiratory tract sources is reported by age groups (0-18, 19-65, and >65 years).
Antimicrobial susceptibility of isolates, collected as part of the ATLAS program (2017-2019), was performed per EUCAST/CLSI guidelines.
S. aureus (N = 7103; methicillin-susceptible S. aureus [MSSA] = 4203; methicillin-resistant S. aureus [MRSA] = 2791), S. pneumoniae (N = 4823; EUCAST/CLSI, penicillin-intermediate S. pneumoniae [PISP] = 1408/870; penicillin-resistant S. pneumoniae [PRSP] = 455/993), and H. influenzae (N = 3850; β-lactamase [βL]-negative = 3097; βL-positive = 753) isolates were collected from respiratory tract specimens. Susceptibility to ceftaroline was 89.08%-97.83% for S. aureus, 99.95%-100% for MSSA, and 78.07%-92.74% for MRSA isolates across age groups; S. aureus as well as MRSA isolates derived from the 0-18 years age group demonstrated the highest susceptibility rates to ceftaroline. Susceptibility to ceftaroline was 98.25%-99.77% for S. pneumoniae, 99.74%-100% for PISP, and 86.23%-99.04% for PRSP isolates across age groups. Across all age groups, susceptibility to ceftaroline was 89.53%-99.70% for H. influenzae, 93.02%-100% for βL-negative, and 77.78%-98.35% for βL-positive isolates.
Irrespective of age, susceptibility to ceftaroline was high among the majority of S. aureus, S. pneumoniae, and H. influenzae isolates collected in this study.
头孢他啶是治疗社区获得性肺炎（CAP）的重要治疗选择。报告了从确定的呼吸道来源收集的来自全球的金黄色葡萄球菌、肺炎链球菌和流感嗜血杆菌分离株的头孢他啶和其他抗菌药物的药敏结果，按年龄组（0-18 岁、19-65 岁和>65 岁）进行分类。
采用 EUCAST/CLSI 指南对 ATLAS 项目（2017-2019 年）收集的分离株进行抗菌药物敏感性检测。
金黄色葡萄球菌（N=7103；甲氧西林敏感金黄色葡萄球菌[MSSA]=4203；甲氧西林耐药金黄色葡萄球菌[MRSA]=2791）、肺炎链球菌（N=4823；EUCAST/CLSI，青霉素中介性肺炎链球菌[PISP]=1408/870；青霉素耐药性肺炎链球菌[PRSP]=455/993）和流感嗜血杆菌（N=3850；β-内酰胺酶[βL]-阴性=3097；βL-阳性=753）分离株均从呼吸道标本中采集。头孢他啶对金黄色葡萄球菌的敏感性为 89.08%-97.83%，对 MSSA 为 99.95%-100%，对 MRSA 为 78.07%-92.74%，各年龄组均如此；0-18 岁年龄组的金黄色葡萄球菌和 MRSA 分离株对头孢他啶的敏感性最高。头孢他啶对肺炎链球菌的敏感性为 98.25%-99.77%，对 PISP 为 99.74%-100%，对 PRSP 为 86.23%-99.04%，各年龄组均如此。在所有年龄组中，头孢他啶对流感嗜血杆菌的敏感性为 89.53%-99.70%，对βL-阴性为 93.02%-100%，对βL-阳性为 77.78%-98.35%。
在所研究的金黄色葡萄球菌、肺炎链球菌和流感嗜血杆菌分离株中，无论年龄大小，头孢他啶的敏感性均很高。
