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肥胖受试者髂骨结构与重塑的组织形态计量学测定

A histomorphometric determination of iliac bone structure and remodeling in obese subjects.

作者信息

Steiniche T, Vesterby A, Eriksen E F, Mosekilde L, Melsen F

出版信息

Bone. 1986;7(2):77-82. doi: 10.1016/8756-3282(86)90677-0.

DOI:10.1016/8756-3282(86)90677-0
PMID:3718787
Abstract

Quantitative histomorphometric analyses of iliac crest biopsies were performed after tetracycline double labeling in 24 patients with morbid obesity and in 30 age- and sex-matched controls. The amount and structure of bone were determined from measurements of total biopsy length, fractional length of medullary space, fractional trabecular bone volume, trabecular thickness, and the intertrabecular distance. Static and dynamic variables of bone resorption and formation were determined, and the balance of the BMU level was estimated from final resorption depth and mean wall thickness of trabecular structural units. In the obese patients the total biopsy length was increased, with a normal proportion of medullary space to total biopsy length. The mean fractional trabecular bone volume was reduced due to an increased distance between trabeculae of normal mean thickness. The total biopsy length in the obese patients was found to be positively related to the intertrabecular distance and inversely related to the fractional trabecular bone volume. The remaining histomorphometric variables describing bone formation rate at tissue, BMU, and cellular levels, the amount of bone formed, the mineralization process, mineralization lag time, bone resorption, and the balance between resorption and formation were all normal in the obese group.

摘要

对24例病态肥胖患者及30例年龄和性别匹配的对照者进行四环素双重标记后,对髂嵴活检组织进行了定量组织形态计量学分析。通过测量活检组织的总长度、髓腔空间的分数长度、骨小梁体积分数、骨小梁厚度和骨小梁间距来确定骨的数量和结构。测定了骨吸收和形成的静态和动态变量,并根据最终吸收深度和骨小梁结构单元的平均壁厚度估算了骨重建单位(BMU)水平的平衡。肥胖患者的活检组织总长度增加,髓腔空间与活检组织总长度的比例正常。由于正常平均厚度的骨小梁之间的距离增加,平均骨小梁体积分数降低。发现肥胖患者的活检组织总长度与骨小梁间距呈正相关,与骨小梁体积分数呈负相关。肥胖组中描述组织、BMU和细胞水平骨形成率、形成的骨量、矿化过程、矿化延迟时间、骨吸收以及吸收与形成之间平衡的其余组织形态计量学变量均正常。

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