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使用泰波罗连续静脉-静脉血液透析快速清除一名严重锂中毒患者体内的锂。

The use of Tablo continuous veno-venous haemodialysis to rapidly remove lithium in a patient with severe lithium toxicity.

作者信息

Nohomovich Brian, Tito Emmanuel, Terrio Michael, Belardo Matthew

机构信息

Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA

Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

出版信息

BMJ Case Rep. 2023 May 15;16(5):e253467. doi: 10.1136/bcr-2022-253467.

DOI:10.1136/bcr-2022-253467
PMID:37188487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10186455/
Abstract

We report a case of severe, life-threatening lithium toxicity in a patient with bipolar I disorder who presented with altered mental status and acute renal failure. At admission, serum lithium level was well above toxic levels (>2 mEq/L). The signs and symptoms of lithium toxicity significantly improved after treatment with continuous veno-venous haemodialysis (CVVHD). The patient was discharged with no neurological or renal sequelae. Herein is the first case report using the Tablo CVVHD system to treat severe lithium toxicity.

摘要

我们报告了一例患有双相 I 型障碍的患者出现严重的、危及生命的锂中毒,该患者表现为精神状态改变和急性肾衰竭。入院时,血清锂水平远高于中毒水平(>2 mEq/L)。经连续性静脉 - 静脉血液透析(CVVHD)治疗后,锂中毒的体征和症状明显改善。患者出院时无神经或肾脏后遗症。本文是首例使用 Tablo CVVHD 系统治疗严重锂中毒的病例报告。

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本文引用的文献

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Extension of Tablo TrEatmeNt Duration (XTEND) study: successful 24 h prolonged therapy with Tablo in critical patients.Tablo 治疗时间延长(XTEND)研究的扩展:Tablo 在危重症患者中成功进行 24 小时延长治疗。
BMC Nephrol. 2022 Oct 21;23(1):338. doi: 10.1186/s12882-022-02968-4.
2
Severe methanol poisoning treated with a novel hemodialysis system: a case report, analysis, and review.采用新型血液透析系统治疗严重甲醇中毒:一例报告、分析及文献复习
Ren Replace Ther. 2021;7(1):43. doi: 10.1186/s41100-021-00362-8. Epub 2021 Aug 3.
3
Safety and efficacy of the Tablo hemodialysis system for in-center and home hemodialysis.Tablo血液透析系统用于中心血液透析和家庭血液透析的安全性与有效性。
Hemodial Int. 2020 Jan;24(1):22-28. doi: 10.1111/hdi.12795. Epub 2019 Nov 7.
4
Continuous Renal Replacement Therapy: Who, When, Why, and How.连续性肾脏替代治疗:谁、何时、为何以及如何。
Chest. 2019 Mar;155(3):626-638. doi: 10.1016/j.chest.2018.09.004. Epub 2018 Sep 25.
5
Lithium-Associated Hypercalcemia: Pathophysiology, Prevalence, Management.锂相关性高钙血症:病理生理学、患病率、管理
World J Surg. 2018 Feb;42(2):415-424. doi: 10.1007/s00268-017-4328-5.
6
Lithium Poisoning.锂中毒
J Intensive Care Med. 2017 May;32(4):249-263. doi: 10.1177/0885066616651582. Epub 2016 Aug 11.
7
What we need to know about the effect of lithium on the kidney.我们需要了解锂对肾脏的影响。
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1168-F1171. doi: 10.1152/ajprenal.00145.2016. Epub 2016 Apr 27.
8
Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis.水通道蛋白-2在肾脏中的调节:体液平衡的分子机制。
Kidney Res Clin Pract. 2013 Sep;32(3):96-102. doi: 10.1016/j.krcp.2013.07.005. Epub 2013 Aug 27.
9
Is it useful to increase dialysate flow rate to improve the delivered Kt?增加透析液流速以提高透析剂量(Kt)是否有用?
BMC Nephrol. 2015 Feb 14;16:20. doi: 10.1186/s12882-015-0013-9.
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alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.αENaC介导的锂吸收促进肾性尿崩症。
J Am Soc Nephrol. 2011 Feb;22(2):253-61. doi: 10.1681/ASN.2010070734. Epub 2010 Nov 4.