Kamaeva Daria A, Kazantseva Daria V, Boiko Anastasiia S, Mednova Irina A, Smirnova Liudmila P, Kornetova Elena G, Ivanova Svetlana A
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str. 4, Tomsk 634014, Russia.
Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky Trakt, 2, Tomsk 634050, Russia.
Biomedicines. 2023 Apr 14;11(4):1179. doi: 10.3390/biomedicines11041179.
Catalytic antibodies, or abzymes, are capable of not only binding but also hydrolyzing various proteins. Previously, an increase in the level of myelin basic protein (MBP)-hydrolyzing activity of antibodies was shown in patients with a number of neurological and mental disorders, including schizophrenia. Furthermore, antipsychotic therapy is known to induce a change in cytokine levels in patients with schizophrenia, which affects regulation of the immune response and inflammatory status. This study investigated the influence of typical and atypical antipsychotics on catalytic antibody activity and the 10 major pro- and anti-inflammatory serum cytokine levels. The study included 40 patients with schizophrenia: 15 treated with first-generation antipsychotics and 25 treated with atypical antipsychotics for 6 weeks. It was found that treatment with atypical antipsychotics changed the levels of some pro-inflammatory cytokines. Antipsychotic therapy also caused a significant decrease in MBP-hydrolyzing activity in patients with schizophrenia ( = 0.0002), and associations of catalytic activity with interleukins were observed.
催化抗体，即抗体酶，不仅能够结合，还能够水解各种蛋白质。此前，在包括精神分裂症在内的一些神经和精神疾病患者中，已显示出抗体的髓鞘碱性蛋白（MBP）水解活性水平有所增加。此外，已知抗精神病治疗会导致精神分裂症患者细胞因子水平发生变化，这会影响免疫反应调节和炎症状态。本研究调查了典型和非典型抗精神病药物对催化抗体活性以及10种主要促炎和抗炎血清细胞因子水平的影响。该研究纳入了40名精神分裂症患者：15名接受第一代抗精神病药物治疗，25名接受非典型抗精神病药物治疗6周。结果发现，非典型抗精神病药物治疗改变了一些促炎细胞因子的水平。抗精神病治疗还导致精神分裂症患者的MBP水解活性显著降低（P = 0.0002），并且观察到催化活性与白细胞介素之间的关联。
