Kohn J, Langer R
Biomaterials. 1986 May;7(3):176-82. doi: 10.1016/0142-9612(86)90098-0.
Poly(iminocarbonates), based on diphenols such as hydroquinone or Bisphenol A were synthesized. Poly(iminocarbonates) degraded under physiological conditions. Compression moulded discs of poly-(hydroquinone-iminocarbonate) showed near zero-order release for low loadings (1%, w/w) of Eosin Y. Poly(Bisphenol A-iminocarbonate) formed transparent films and strong fibres. It is a tough polymer with high tensile strength. Under physiological conditions complete erosion of a thin film of poly(Bisphenol A-iminocarbonate) required about 200 d. The release profile for p-nitroaniline from solvent cast films of poly(Bisphenol A-iminocarbonate) was characterized by a lag period (20 d), followed by near zero-order release for 90 d. Initial toxicological studies revealed no inflammatory cell response after implantation in the corneas of rabbits or subcutaneously in mice.
合成了基于对苯二酚或双酚A等二酚的聚亚氨基碳酸酯。聚亚氨基碳酸酯在生理条件下会降解。聚（对苯二酚-亚氨基碳酸酯）的压缩模塑圆盘对低负载量（1%，w/w）的曙红Y显示出接近零级释放。聚（双酚A-亚氨基碳酸酯）形成透明薄膜和坚固的纤维。它是一种具有高拉伸强度的坚韧聚合物。在生理条件下，聚（双酚A-亚氨基碳酸酯）薄膜完全侵蚀需要约200天。聚（双酚A-亚氨基碳酸酯）溶剂浇铸膜对对硝基苯胺的释放曲线特征为有一个滞后阶段（20天），随后90天接近零级释放。初步毒理学研究表明，植入兔角膜或小鼠皮下后没有炎症细胞反应。
