Iqbal Nosheen, Khalid Muhammad Usman, Janjua Omer Sefvan, Zafar Khurram Jah, Usama Malik Muhammad
Department of Oral and Maxillofacial Surgery, Faisalabad Medical University, Faisalabad, Pakistan.
J Coll Physicians Surg Pak. 2023 May;33(5):504-508. doi: 10.29271/jcpsp.2023.05.504.
To determine the efficacy of Platelet-Rich Fibrin (PRF) in preventing Dry Socket (DS) after mandibular third molar surgery in comparison with the control group.
Experimental study. Place and Duration of the Study: Oral and Maxillofacial Surgery Department, Dental Section, Faisalabad Medical University, Faisalabad, Pakistan, from July 2019 to June 2021.
Patients aged 18-35 years with good oral hygiene, and requiring surgical extraction of their mandibular third molar were included in the study. Those with periodontal disease, pregnant or nursing women, smokers, or allergic to the agents that were recommended for use before and after surgery, were excluded. Patients presenting for surgical removal of the mandibular third molar and meeting the inclusion criteria were enrolled and randomly divided into 2 groups. Standard protocol for tooth removal was followed in both groups. Group1 (study group) received PRF and group 2 (control group) did not receive PRF.
A total of 170 consecutive patients (85/group) were randomly selected and allocated to the study group and control group. The mean age in the study group was 24.28±3.7 years while the mean age in the control group was 24.14±3.64 years. Out of them, 51.2% (n=87) were males and 48.8% (n=83) were females with a M: F of 1:1.05. On the 3rd postoperative day, DS frequency in the study group was 2.4% (n=2) and 18.8% (n=16) in the control group (p=0.0001), which reduced to 01 and 05 respectively on 7th day (p=0.096).
PRF administration was effective in preventing DS on the third postoperative day in mandibular third molar surgery, with statistically significant results. However, on postoperative day 7, the results were not statistically significant.
Third molar, Tooth extraction, Dry socket, PRF.
与对照组相比，确定富血小板纤维蛋白（PRF）在下颌第三磨牙手术后预防干槽症（DS）的疗效。
实验性研究。研究地点和时间：2019年7月至2021年6月，巴基斯坦费萨拉巴德费萨拉巴德医科大学口腔颌面外科牙科。
纳入年龄在18 - 35岁、口腔卫生良好且需要手术拔除下颌第三磨牙的患者。排除患有牙周病、孕妇或哺乳期妇女、吸烟者或对手术前后推荐使用的药物过敏者。前来接受下颌第三磨牙手术且符合纳入标准的患者被纳入研究并随机分为两组。两组均遵循标准拔牙方案。第1组（研究组）接受PRF，第2组（对照组）不接受PRF。
共随机选取170例连续患者（每组85例）并分配到研究组和对照组。研究组的平均年龄为24.28±3.7岁，而对照组的平均年龄为24.14±3.64岁。其中，51.2%（n = 87）为男性，48.8%（n = 83）为女性，男女比例为1:1.05。术后第3天，研究组干槽症发生率为2.4%（n = 2），对照组为18.8%（n = 16）（p = 0.0001），第7天时分别降至01和05（p = 0.096）。
在下颌第三磨牙手术中，术后第3天给予PRF对预防干槽症有效，结果具有统计学意义。然而，术后第7天，结果无统计学意义。
第三磨牙；拔牙；干槽症；PRF
