Motomura N, Yamadori A, Mori E, Tamaru F
Brain. 1986 Jun;109 ( Pt 3):379-91. doi: 10.1093/brain/109.3.379.
We report a case of typical auditory agnosia. It is unique in that the clinical picture began with generalized auditory agnosia for verbal and nonverbal sounds and changed, over a period of two months, to a restricted auditory agnosia, confined to the recognition of nonverbal sounds. The lesions, confirmed by CT scanning and MRI, were subcortical bilaterally, without evidence of cortical damage, and have not previously been described. The results of audiological studies on temporal discrimination were similar to those described for bilateral temporal lobe lesions. The relationships between click intervals and the threshold to detect sound, and between numbers of clicks and the threshold, were also examined. We observed a tendency for the threshold to decline as the number of clicks was increased or the interval between two clicks was shortened. These phenomena are similar to temporal summation in cellular neurophysiology and we speculate that this phenomenon is an important factor in the auditory disturbances shown by the present case.
我们报告一例典型的听觉失认症病例。该病例的独特之处在于，临床表现最初为对言语和非言语声音的广泛性听觉失认，在两个月的时间里逐渐转变为局限性听觉失认，仅局限于对非言语声音的识别。经CT扫描和MRI证实，病变位于双侧皮质下，无皮质损伤迹象，此前未见相关描述。关于时间辨别力的听力学研究结果与双侧颞叶病变的描述相似。我们还研究了点击间隔与声音检测阈值之间以及点击次数与阈值之间的关系。我们观察到，随着点击次数增加或两次点击之间的间隔缩短，阈值有下降的趋势。这些现象类似于细胞神经生理学中的时间总和，我们推测这种现象是本例所表现出的听觉障碍的一个重要因素。
