Effect of butylphthalide injection combined with gastrodin to improve sTRAIL and inflammatory factors in elderly patients with cerebral infarction.

OBJECTIVE

This research was designed to probe into the effect of butylphthalide injection combined with gastrodin on sTRAIL and inflammatory factors in elderly patients with cerebral infarction (CI).

METHODS

Elderly CI patients admitted to the Strategic Support Force Characteristic Medical Center from June 2019 to September 2021 were collected for this retrospective analysis, and then divided into Group A and B. Patients in group A were given gastrodin injection by intravenous drip, and those in group B were treated with butylphthalide injection additionally. The general data, efficacy and adverse reactions of patients were observed and compared. The neurological impairment (NIHSS) score before and after treatment was analyzed. The activities of daily living and Barthel index (BI) after treatment were tested. The levels of sTRAIL and inflammatory factors were assessed before and after treatment. Their quality of life (SF-36 score) was observed before and after treatment. Logistic regression was used to analyze the risk factors affecting patient prognosis.

RESULTS

There was no difference in general data between the two groups (P>0.05). Compared with group A, group B showed higher total effective rate (P<0.05), lower total incidence of adverse reactions (P<0.05), and lower NIHSS scores after treatment (P<0.05). Besides, after treatment, the levels of sTRAIL and inflammatory factors were lower (P<0.05), BI was higher (P<0.05), and the quality of life was better (P<0.05) in group B than in group A. Age and NIHSS score were risk factors for poor prognosis (P<0.05).

CONCLUSION

Butylphthalide injection combined with gastrodin is better than gastrodin alone in the treatment of senile CI. This combination can improve the neurological function and activities of daily living and reduce the levels of serum sTRAIL and inflammatory factors in patients.