De Ronde F S, de Kloet E R, Nyakas C
Brain Res. 1986 May 28;374(2):219-26. doi: 10.1016/0006-8993(86)90415-4.
Unilateral ablation of the right dorsal hippocampus (HCX) produced changes in maximal corticosteroid binding capacity (Bmax) in the contralateral hippocampal lobe of the rat with time. The mechanism by which this time course of changes was produced seemed to involve the pituitary-adrenal system, since a certain difference in corticosteroid receptor binding pattern was noted between chronic adrenalectomized (ADX) rats and rats which remained intact during postlesion survival. In the presence of endogenous adrenal hormones the HCX-induced changes in corticosteroid receptor binding relative to that observed in rats with the overlying neocortex ablated (control) were the following: a 26% decrease at 5 days after HCX; an increase the following 3 weeks with a maximum of 46% at 20 days postsurgery; and recovery towards control values after longer survival times. After discrimination of corticosteroid binding into two corticosterone (CORT) binding receptor populations, e.g. glucocorticoid receptors (GR) and mineralocorticoid-like or CORT receptors (CR), the lesion-induced effect was more pronounced in GR than in CR. A 72% increase over controls was measured at 20 days postsurgery. In the absence of the adrenals, however, the Bmax of corticosteroid binding was not decreased at 5 days after HCX. The relative increase in Bmax reached a maximum of 39% over control levels at 30 days postsurgery and recovery towards control values after longer survival did not occur. The increase in corticosteroid receptor capacity after HCX, therefore, is transient in the presence of adrenocortical secretion and permanent in its absence.(ABSTRACT TRUNCATED AT 250 WORDS)
单侧切除大鼠右侧背侧海马体（HCX）后，其对侧海马叶的最大皮质类固醇结合能力（Bmax）会随时间发生变化。这种变化时间进程的产生机制似乎涉及垂体-肾上腺系统，因为在慢性肾上腺切除（ADX）大鼠和损伤后存活期内保持完整的大鼠之间，观察到皮质类固醇受体结合模式存在一定差异。在内源性肾上腺激素存在的情况下，相对于切除覆盖新皮层的大鼠（对照），HCX诱导的皮质类固醇受体结合变化如下：HCX术后5天降低26%；接下来3周增加，术后20天达到最大值46%；存活时间更长后恢复至对照值。将皮质类固醇结合区分为两种皮质酮（CORT）结合受体群体，即糖皮质激素受体（GR）和盐皮质激素样或CORT受体（CR）后，损伤诱导的效应在GR中比在CR中更明显。术后20天，测量值比对照增加72%。然而，在没有肾上腺的情况下，HCX术后5天皮质类固醇结合的Bmax并未降低。Bmax的相对增加在术后30天达到比对照水平高39%的最大值，存活时间更长后未恢复至对照值。因此，HCX后皮质类固醇受体容量的增加在肾上腺皮质分泌存在时是短暂的，在其不存在时是永久的。（摘要截短于250字）
