Bharwani N
CMAJ. 1986 Jul 15;135(2):128-9.
Appropriate initial surgical management of primary cutaneous malignant melanoma is important since no effective treatment exists once the tumour metastasizes. The author reviews methods of initial treatment, excisional biopsy with adequate margins being the most common. He also reports results from a questionnaire survey on the type of microstaging used at hospitals across Canada. Two thirds of the pathologists who responded to the questionnaire preferred to use both Clark's and Breslow's method of microstaging. As a result, the author believes that the best histopathologic classification to use for predicting outcome has yet to be established.
原发性皮肤恶性黑色素瘤的恰当初始手术管理很重要，因为一旦肿瘤发生转移，就不存在有效的治疗方法。作者回顾了初始治疗方法，其中切除活检并保证足够切缘是最常见的。他还报告了一项关于加拿大各地医院使用的微分期类型的问卷调查结果。回复问卷的病理学家中有三分之二更倾向于同时使用克拉克（Clark）和布雷斯洛（Breslow）微分期方法。因此，作者认为用于预测预后的最佳组织病理学分类尚未确立。
