Shimamatsu K, Fouad-Tarazi F M
Cardiovasc Res. 1986 Apr;20(4):269-74. doi: 10.1093/cvr/20.4.269.
Cardiac performance in renal hypertensive animals has been variously reported as normal, increased, or decreased. Because of the many factors that can alter cardiac function in vivo ventricular contractility was investigated in isolated, paced, isovolumic heart preparations (modified Langendorff). Twenty one hypertensive rats (2 kidney, 1 clip Goldblatt) and 21 matched sham operated controls, were studied. Mean(SD) blood pressure and left ventricular weight were significantly higher in the study rats (228(5) vs 125(2) mmHg and 4.16(0.12) vs 2.35(0.04) mg X kg-1 respectively). In the first experiment performed at 50 mmHg perfusion pressure left ventricular +dP/dt and myocardial flow rate were lower in 12 study rats (mean(SD) 1782(79) vs 2270(105) mmHg X s-1, 5.8(0.4) vs 14.0(1.0) ml X g-1 LV weight X min-1, respectively) than in the controls. In a second experiment performed at 80 mmHg perfusion pressure (nine study hearts and seven controls) the increased myocardial flow rate resulted in a higher left ventricular +dP/dt in both groups, but the study hearts still had a lower mean(SD) myocardial flow rate than the controls (12.5(0.9) vs 19.8(2.2) ml X g-1 LV weight X min-1; the difference in left ventricular +dP/dt became non-significant (2646(186) vs 2951(136) mmHg X s-1). Similarly, at equal myocardial flow rates (study hearts at 80 mmHg perfusion pressure and controls at 50 mmHg perfusion pressure) ventricular performance was similar in the two groups (mean(SD) left ventricular +dP/dt 2270(105) in controls vs 2646(186) mmHg X s-1 in study hearts).(ABSTRACT TRUNCATED AT 250 WORDS)
关于肾性高血压动物的心脏功能，已有多种报道称其正常、增强或减弱。由于体内有许多因素可改变心脏功能，因此在离体、起搏、等容心脏标本（改良Langendorff法）中研究了心室收缩性。研究了21只高血压大鼠（双肾单夹Goldblatt模型）和21只匹配的假手术对照组大鼠。研究大鼠的平均（标准差）血压和左心室重量显著更高（分别为228（5）与125（2）mmHg以及4.16（0.12）与2.35（0.04）mg·kg-1）。在首次实验中，灌注压为50 mmHg时，12只研究大鼠的左心室 +dP/dt和心肌血流量较低（平均（标准差）分别为1782（79）与2270（105）mmHg·s-1，5.8（0.4）与14.0（1.0）ml·g-1左心室重量·min-1），低于对照组。在第二次实验中，灌注压为80 mmHg（9只研究心脏和7只对照），心肌血流量增加导致两组左心室 +dP/dt均升高，但研究心脏的平均（标准差）心肌血流量仍低于对照组（12.5（0.9）与19.8（2.2）ml·g-1左心室重量·min-1；左心室 +dP/dt的差异变得不显著（2646（186）与2951（136）mmHg·s-1）。同样，在心肌血流量相等时（研究心脏在80 mmHg灌注压，对照组在50 mmHg灌注压），两组的心室功能相似（对照组平均（标准差）左心室 +dP/dt为2270（105），研究心脏为2646（186）mmHg·s-1）。（摘要截断于250字）
