空气污染、EGFR 突变与癌症发生。

Air pollution, EGFR mutation, and cancer initiation.

机构信息

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

出版信息

Cell Rep Med. 2023 May 16;4(5):101046. doi: 10.1016/j.xcrm.2023.101046.

DOI:10.1016/j.xcrm.2023.101046

PMID:37196632

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10213952/

Abstract

Swanton et al. find that PM exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

摘要

斯旺顿等人发现，PM 暴露与 EGFR/KRAS 驱动的肺癌发病率有关。PM 通过间质巨噬细胞分泌的 IL-1β 增加 EGFR 前突变的肺泡 II 型细胞祖细胞功能和致瘤活性，为抑制癌症发生提供了潜在的预防方法。