高亲和力钙与平滑肌质膜的结合：阳离子的抑制作用。
High affinity Ca-binding to smooth muscle plasma membrane: inhibition by cations.
作者信息
Grover A K, Kwan C Y
出版信息
Cell Calcium. 1986 Jun;7(3):187-92. doi: 10.1016/0143-4160(86)90022-9.
The effects of Mg2+, Na+ and K+ on the pH-dependent high affinity passive Ca-binding to sarcolemmal enriched membrane fractions from the smooth muscles of rat myometrium and gastric fundus were examined at 1 uM Ca2+-concentration. For the myometrial plasma membranes, these ions inhibited the passive Ca-binding with the following IC50 values: Mg2+: 1.75 mM; Na+: 19 mM; K+: 233 mM. Similarly, for the gastric fundus membranes, the IC50 values were Mg2+:1.6 mM, Na+:46 mM and K+:67 mM.
在钙离子浓度为1微摩尔时，研究了镁离子、钠离子和钾离子对大鼠子宫肌层和平滑肌胃底富含肌膜的膜组分中pH依赖性高亲和力被动钙结合的影响。对于子宫肌层质膜，这些离子抑制被动钙结合，其半数抑制浓度（IC50）值如下：镁离子：1.75毫摩尔；钠离子：19毫摩尔；钾离子：233毫摩尔。同样，对于胃底膜，IC50值分别为：镁离子1.6毫摩尔、钠离子46毫摩尔和钾离子67毫摩尔。
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