State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; School of Hebei Sciences & Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China.
State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; School of Hebei Sciences & Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China.
Brain Res. 2023 Aug 15;1813:148408. doi: 10.1016/j.brainres.2023.148408. Epub 2023 May 15.
Theta burst stimulation (TBS), a highly efficient repetitive transcranial magnetic stimulation (rTMS) paradigm, has been widely used to modulate the working memory (WM) ability in experimental and clinical study. However, the underly neuroelectrophysiological mechanism remains unclear. The aim of this study was to compare the effect of iTBS, cTBS and rTMS on WM and explore the neural oscillatory communication changes in PFC involved in spatial WM task. 18 rats were treated by iTBS, cTBS and rTMS respectively (n = 6 each), while the rats in control group (n = 6) received no stimulation. T-maze WM task was used to assess the rats' performance of WM after stimulation. Local field potentials (LFPs) were recorded from a microelectrode array implanted in the medial prefrontal cortex (mPFC) while the rats were performing the WM task. Functional connectivity (FC) strength was assessed by LFP-LFP coherence calculations. The results showed that the rats from the rTMS group and iTBS group are able to reach criteria in less time than the control group's duration of the T-maze task. The power and the coherence value of rTMS and iTBS groups show a significant increase in the theta-band and gamma-band activity, wheras there are no significant differences of the energy and the coherence value between the cTBS group and the control group in theta-band. Furthermore, significantly positive correlations were observed between changes of memory performance during the WM task and the changes of the coherence value of the LFPs. In conclusion, these results indicate that rTMS and iTBS may improve the ability of WM by modulating the neural activity and connectivity in PFC.
经颅磁刺激（TBS）是一种高效的重复经颅磁刺激（rTMS）范式，已广泛应用于实验和临床研究中调节工作记忆（WM）能力。然而，其潜在的神经电生理机制仍不清楚。本研究旨在比较 iTBS、cTBS 和 rTMS 对 WM 的影响，并探讨参与空间 WM 任务的 PFC 中神经振荡通讯变化。18 只大鼠分别接受 iTBS、cTBS 和 rTMS 治疗（n=6 只/组），而对照组（n=6 只）大鼠未接受刺激。T 迷宫 WM 任务用于评估刺激后大鼠 WM 的表现。在大鼠执行 WM 任务时，从植入内侧前额叶皮质（mPFC）的微电极阵列中记录局部场电位（LFP）。通过 LFP-LFP 相干性计算评估功能连接（FC）强度。结果显示，rTMS 组和 iTBS 组的大鼠完成 T 迷宫任务的时间比对照组的时间更短。rTMS 和 iTBS 组的功率和相干值在θ波段和γ波段的活动显著增加，而 cTBS 组与对照组在θ波段的能量和相干值没有显著差异。此外，在 WM 任务期间记忆表现的变化与 LFPs 的相干值变化之间观察到显著的正相关。总之，这些结果表明 rTMS 和 iTBS 可能通过调节 PFC 中的神经活动和连接来提高 WM 能力。
