Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.
Department of Emergency Surgery, The Fourth Affiliated Hospital of Jiangsu University (Zhenjiang Fourth People's Hospital), Zhenjiang, China.
Int Wound J. 2023 Nov;20(9):3840-3854. doi: 10.1111/iwj.14231. Epub 2023 May 17.
Wound healing is an extremely complex process involving multiple levels of cells and tissues. It is mainly completed through four stages: haemostasis, inflammation, proliferation, and remodelling. When any one of these stages is impaired, it may lead to delayed healing or even transformation into chronic refractory wounds. Diabetes is a kind of common metabolic disease that affects approximately 500 million people worldwide, 25% of whom develop skin ulcers that break down repeatedly and are difficult to heal, making it a growing public health problem. Neutrophils extracellular traps and ferroptosis are new types of programmed cell death identified in recent years and have been found to interact with diabetic wounds. In this paper, the normal wound healing and interfering factors of the diabetic refractory wound were outlined. The mechanism of two kinds of programmed cell death was also described, and the interaction mechanism between different types of programmed cell death and diabetic refractory wounds was discussed.
伤口愈合是一个极其复杂的过程，涉及多个层次的细胞和组织。它主要通过四个阶段完成：止血、炎症、增殖和重塑。当这些阶段中的任何一个受到损害时，可能会导致愈合延迟，甚至转化为慢性难治性伤口。糖尿病是一种常见的代谢性疾病，全球约有 5 亿人受到影响，其中 25%的人会出现皮肤溃疡，这些溃疡会反复破裂且难以愈合，成为日益严重的公共卫生问题。中性粒细胞胞外诱捕网和铁死亡是近年来发现的新型程序性细胞死亡方式，已发现它们与糖尿病性伤口相互作用。本文概述了正常伤口愈合和糖尿病难治性伤口的干扰因素。还描述了两种程序性细胞死亡的机制，并讨论了不同类型的程序性细胞死亡与糖尿病难治性伤口之间的相互作用机制。
