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CD49d in chronic lymphocytic leukemia: a molecule with multiple regulation layers. Comment to "Sialylation regulates migration in chronic lymphocytic leukemia".慢性淋巴细胞白血病中的CD49d：一个具有多重调控层面的分子。对“Sialylation regulates migration in chronic lymphocytic leukemia”的评论
Haematologica. 2024 Jan 1;109(1):362-363. doi: 10.3324/haematol.2023.283237.
2
CD49d shows superior performance characteristics for flow cytometric prognostic testing in chronic lymphocytic leukemia/small lymphocytic lymphoma.CD49d 在慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的流式细胞术预后检测中具有优越的性能特征。
Cytometry B Clin Cytom. 2018 Jan;94(1):129-135. doi: 10.1002/cyto.b.21384. Epub 2016 Jun 27.
3
The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.慢性淋巴细胞白血病中预后标志物 CD38 和 CD49d 的致病相关性。
Ann Hematol. 2014 Mar;93(3):361-74. doi: 10.1007/s00277-013-1967-y. Epub 2013 Nov 28.
4
Low CD49d expression in newly diagnosed chronic lymphocytic leukaemia may be associated with high-risk features and reduced treatment-free-intervals.新诊断的慢性淋巴细胞白血病中 CD49d 表达水平低可能与高危特征和无治疗间期缩短有关。
Eur J Haematol. 2022 Nov;109(5):441-446. doi: 10.1111/ejh.13824. Epub 2022 Aug 9.
5
CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.CD49d 是一个独立的预后标志物，与 CLL 中 CXCR4 的表达相关。
Leuk Res. 2011 Jun;35(6):750-6. doi: 10.1016/j.leukres.2010.10.022. Epub 2010 Nov 18.
6
Sialylation regulates migration in chronic lymphocytic leukemia.唾液酸化调节慢性淋巴细胞白血病中的迁移。
Haematologica. 2023 Jul 1;108(7):1851-1860. doi: 10.3324/haematol.2022.281999.
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CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.CD49d 是慢性淋巴细胞白血病中基于流式细胞术的最强总生存预测因子。
J Clin Oncol. 2014 Mar 20;32(9):897-904. doi: 10.1200/JCO.2013.50.8515. Epub 2014 Feb 10.
8
CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance.B 细胞慢性淋巴细胞白血病中的 CD49d：与 CD38 的相关性表达及预后意义
Leukemia. 2006 Mar;20(3):523-5; author reply 528-9. doi: 10.1038/sj.leu.2404087.
9
Overexpression of CD49d in trisomy 12 chronic lymphocytic leukemia patients is mediated by IRF4 through induction of IKAROS.12号染色体三体慢性淋巴细胞白血病患者中CD49d的过表达由IRF4通过诱导IKAROS介导。
Leukemia. 2019 May;33(5):1278-1302. doi: 10.1038/s41375-018-0296-5. Epub 2019 Jan 18.
10
Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression.荧光原位杂交分析中的核型演变与慢性淋巴细胞白血病患者的短生存期相关，且与CD49d表达有关。
J Clin Oncol. 2008 May 10;26(14):e5-6. doi: 10.1200/JCO.2008.16.7874.

本文引用的文献

1
Sialylation regulates migration in chronic lymphocytic leukemia.唾液酸化调节慢性淋巴细胞白血病中的迁移。
Haematologica. 2023 Jul 1;108(7):1851-1860. doi: 10.3324/haematol.2022.281999.
2
CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression.CD49d 促进慢性淋巴细胞白血病的疾病进展：来自 CD49d 双模态表达的新见解。
Blood. 2020 Apr 9;135(15):1244-1254. doi: 10.1182/blood.2019003179.
3
Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.唾液酸转移酶抑制导致肿瘤细胞与 E-选择素、VCAM1 和 MADCAM1 的相互作用受到抑制，并改善了人类多发性骨髓瘤小鼠模型的存活率。
Haematologica. 2020 Jan 31;105(2):457-467. doi: 10.3324/haematol.2018.212266. Print 2020.
4
Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.伊布替尼治疗慢性淋巴细胞白血病中 VLA-4（CD49d/CD29）的功能和临床相关性。
J Exp Med. 2018 Feb 5;215(2):681-697. doi: 10.1084/jem.20171288. Epub 2018 Jan 4.
5
NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways.NOTCH1 突变与慢性淋巴细胞白血病中高 CD49d 表达相关：NOTCH1 与 NF-κB 通路的联系。
Leukemia. 2018 Mar;32(3):654-662. doi: 10.1038/leu.2017.296. Epub 2017 Sep 22.
6
CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia.CD49d 优于新型复发突变，是慢性淋巴细胞白血病总生存的独立预后因子。
Leukemia. 2016 Oct;30(10):2011-2018. doi: 10.1038/leu.2016.88. Epub 2016 Apr 25.
7
CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism.CD49d 在 12 三体慢性淋巴细胞白血病细胞中过表达：证据表明存在一种依赖于甲基化的调控机制。
Blood. 2013 Nov 7;122(19):3317-21. doi: 10.1182/blood-2013-06-507335. Epub 2013 Sep 25.
8
The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells.CD49d/CD29 复合物在物理和功能上与 B 细胞慢性淋巴细胞白血病细胞中的 CD38 相关联。
Leukemia. 2012 Jun;26(6):1301-12. doi: 10.1038/leu.2011.369. Epub 2012 Jan 6.
9
CD38 and chronic lymphocytic leukemia: a decade later.CD38 与慢性淋巴细胞白血病：十年后。
Blood. 2011 Sep 29;118(13):3470-8. doi: 10.1182/blood-2011-06-275610. Epub 2011 Jul 15.
10
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.CLL 细胞表面 IgM 呈现出异常的聚糖，表明体内抗原的结合。
Blood. 2010 May 27;115(21):4198-205. doi: 10.1182/blood-2009-12-254847. Epub 2010 Mar 17.

CD49d in chronic lymphocytic leukemia: a molecule with multiple regulation layers. Comment to "Sialylation regulates migration in chronic lymphocytic leukemia".

作者信息

Pozzo Federico, Tissino Erika, Zucchetto Antonella, Gattei Valter

机构信息

Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano.

出版信息

Haematologica. 2024 Jan 1;109(1):362-363. doi: 10.3324/haematol.2023.283237.

DOI:10.3324/haematol.2023.283237
PMID:37199129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10772489/
Abstract
摘要