二(乙酰丙酮)合二铑配合物与 B-DNA 十二聚体的结合：X 射线晶体学和质谱研究。

Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry.

机构信息

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo via Cintia, I-80126 Napoli, Italy.

Department of Chemistry "U. Schiff", University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.

出版信息

Dalton Trans. 2023 May 30;52(21):6992-6996. doi: 10.1039/d3dt00320e.

DOI:10.1039/d3dt00320e

PMID:37199244

Abstract

The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion.

摘要

通过 X 射线晶体学和质谱研究了细胞毒性化合物二醋酸合二价铑与 B-DNA 双螺旋十二聚体的反应。二价铑/DNA 加合物的结构揭示了一个双金属中心与腺嘌呤轴向配位结合。通过 ESI MS 测量获得了补充信息。将目前的数据与以前获得的顺铂数据进行比较表明，这两种金属药物以明显不同的方式与这种 DNA 十二聚体反应。