Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Rajkot, Gujarat, India.
Department of Radiology, P.D.U. Medical College, Rajkot, India.
Crit Rev Oncog. 2022;27(4):47-64. doi: 10.1615/CritRevOncog.2022047088.
Oral cancer has become a significant problem throughout the world, particularly in countries that are still developing. Recent literature supports the contribution of components of the tumor microenvironment (TME) and the effect of epigenetic changes happening in the cells of the TME on oral cancer development and progression. In this review, we comprehensively examine the significance of TME in the development of OC along with the current understanding of the epigenetic modifications that regulate the TME and their cohesive impact on tumor traits and their potential as therapeutic targets.
口腔癌已成为全球范围内的一个重大问题，尤其是在那些仍处于发展阶段的国家。最近的文献支持肿瘤微环境（TME）的成分以及 TME 细胞中发生的表观遗传变化对口腔癌发展和进展的影响。在这篇综述中，我们全面研究了 TME 在 OC 发展中的重要性，以及目前对调节 TME 的表观遗传修饰的理解，以及它们对肿瘤特征的协同影响及其作为治疗靶点的潜力。
