Undesser K P, Trapani A J, Morgan W W, Bishop V S
Circ Res. 1986 Jun;58(6):882-9. doi: 10.1161/01.res.58.6.882.
This study compares the effect of arginine-vasopressin and phenylephrine on renal sympathetic nerve activity, arterial pressure, and heart rate in vehicle- and intraventricular 6-hydroxydopamine-treated conscious rabbits. In addition, this study examines the involvement of forebrain structures on these variables. In vehicle-treated rabbits, compared to phenylephrine, vasopressin produces a greater decrease in renal sympathetic nerve activity and heart rate for a given increase in pressure. After administration of intraventricular 6-hydroxydopamine, the responses produced with vasopressin are similar to those produced with phenylephrine. Analysis of catecholamine content in the nucleus of the solitary tract, parabrachial nucleus, area postrema, and spinal cord indicates that the only regions of significant catecholamine depletion are in the nucleus of the solitary tract and the spinal cord. Transection at the mid-collicular level does not alter significantly the responses of vasopressin or phenylephrine on renal sympathetic nerve activity or heart rate. This indicates that forebrain structures are not involved in mediating the enhanced buffering effect produced with vasopressin.
本研究比较了精氨酸加压素和去氧肾上腺素对经脑室注射6-羟基多巴胺处理的清醒家兔和未处理清醒家兔的肾交感神经活动、动脉血压及心率的影响。此外，本研究还考察了前脑结构对这些变量的影响。在未处理的家兔中，对于给定的压力升高，与去氧肾上腺素相比，加压素可使肾交感神经活动和心率出现更大程度的降低。脑室注射6-羟基多巴胺后，加压素产生的反应与去氧肾上腺素产生的反应相似。对孤束核、臂旁核、最后区和脊髓中的儿茶酚胺含量分析表明，儿茶酚胺显著耗竭的唯一区域是孤束核和脊髓。在中脑水平横断并不显著改变加压素或去氧肾上腺素对肾交感神经活动或心率的反应。这表明前脑结构不参与介导加压素产生的增强缓冲效应。
