Hannibal Niels, Pedersen Inge Nygaard, Bertelsen Lars Rye, Nielsen René Ernst, Gold Christian
Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.
Aalborg University Hospital - Psychiatry, Aalborg, Denmark.
Front Psychiatry. 2023 May 2;14:1120003. doi: 10.3389/fpsyt.2023.1120003. eCollection 2023.
Examine whether change in clinical outcomes for patients with schizophrenia and negative symptoms randomized to either Music Therapy (MT) or Music Listening (ML) is associated to moderators and mediators, with focus on alliance, attendance and dropout.
An exploratory post-hoc analysis of data from an original randomized controlled trial (RCT) investigating the effect of MT vs. ML for people with schizophrenia and negative symptoms. Inclusion to the study was implemented through screening of referred patients for symptoms of schizophrenia and negative symptoms. A total of 57 patients were randomly assigned, 28 to MT and 29 to ML. Session logs and notes were included in this study. Statistical analysis investigated moderator and mediator relation to outcome variables: Negative symptoms, functioning, quality of life, and retention to treatment.
On average, participants in MT attended 18.86 sessions (SD = 7.17), whereas those in ML attended 12.26 (SD = 9.52), a statistically significant difference ( = 0.0078). Dropout at 25 weeks was predicted by intervention, with dropout being 2.65 (SE = 1.01) times more likely in ML than in music therapy ( = 0.009). Helping alliance score at weeks was explained by intervention, with mean score being 0.68 (SE = 0.32) points lower in ML than in MT ( = 0.042). The number of sessions attended was also explained by intervention, with participants in ML attending on average 6.17 (SE = 2.24) fewer sessions than those randomized to MT ( = 0.008). Though both groups improved significantly, improvements in negative symptoms, depression, and functioning tended to be higher in ML, whereas improvements in alliance and quality of life tended to be higher in MT.
The analysis could not detect a direct link between helping alliance score and outcome variables. However, the analysis documented a stronger alliance developed in the MT group, a lower dropout rate, as well as higher attendance in treatment.: www.ClinicalTrials.gov, identifier: NCT02942459.
研究随机分配至音乐治疗（MT）或音乐聆听（ML）组的精神分裂症及阴性症状患者的临床结局变化是否与调节因素和中介因素相关，重点关注治疗联盟、治疗参与度和退出率。
对一项原始随机对照试验（RCT）的数据进行探索性事后分析，该试验研究MT与ML对精神分裂症及阴性症状患者的疗效。通过筛查转诊患者的精神分裂症和阴性症状来纳入研究。总共57名患者被随机分配，28名至MT组，29名至ML组。本研究纳入了治疗记录和笔记。统计分析调查调节因素和中介因素与结局变量的关系：阴性症状、功能、生活质量和治疗保留率。
平均而言，MT组的参与者参加了18.86次治疗（标准差=7.17），而ML组的参与者参加了12.26次（标准差=9.52），差异具有统计学意义（P=0.0078）。干预可预测25周时的退出率，ML组退出的可能性是音乐治疗组的2.65倍（标准误=1.01，P=0.009）。干预可解释各周的治疗联盟得分，ML组的平均得分比MT组低0.68分（标准误=0.32，P=0.042）。干预也可解释治疗参与次数，ML组的参与者平均比随机分配至MT组的参与者少参加6.17次治疗（标准误=2.24，P=0.008）。尽管两组均有显著改善，但ML组在阴性症状、抑郁和功能方面的改善往往更高，而MT组在治疗联盟和生活质量方面的改善往往更高。
该分析未发现治疗联盟得分与结局变量之间的直接联系。然而，分析表明MT组形成了更强的治疗联盟，退出率更低，治疗参与度更高。：ClinicalTrials.gov，标识符：NCT02942459
