铁缺乏及其对铁稳态的表观遗传影响。

Iron deficiency and its epigenetic effects on iron homeostasis.

机构信息

Department of Biochemistry and Molecular Biology, Faculty of Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.

Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 13110, Jordan; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.

出版信息

J Trace Elem Med Biol. 2023 Jul;78:127203. doi: 10.1016/j.jtemb.2023.127203. Epub 2023 May 15.

DOI:10.1016/j.jtemb.2023.127203

PMID:37201368

Abstract

Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1-3 (TET 1-3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1-3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed.

摘要

铁缺乏是一种常见的微量营养素缺乏症，与铁调节蛋白、hepcidin 和 ferroportin 水平的代谢变化有关。研究表明，铁稳态失调与其他继发性和危及生命的疾病有关，包括贫血、神经退行性疾病和代谢性疾病。铁缺乏通过影响 Fe/α-酮戊二酸依赖性去甲基化酶，Ten Eleven Translocase 1-3（TET 1-3）和 Jumonji-C（JmjC）组蛋白去甲基酶，在表观遗传调控中发挥关键作用，这两种酶分别参与 DNA 和组蛋白尾部上甲基化标记的表观遗传擦除。在这篇综述中，讨论了与铁缺乏相关的表观遗传效应以及 TET 1-3 和 JmjC 组蛋白去甲基酶活性对 hepcidin/ferroportin 轴的影响。