Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China; The Fourth Clinical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
The Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, China.
Asian J Psychiatr. 2023 Jul;85:103618. doi: 10.1016/j.ajp.2023.103618. Epub 2023 May 6.
We aimed to systematically evaluate the clinical efficacy and safety of accelerated intermittent theta burst stimulation (aiTBS) for patients with major depressive disorder (MDD) or bipolar depression (BD). A random-effects model was adopted to analyze the primary and secondary outcomes using the Review Manager, Version 5.3 software. This meta-analysis (MA) identified five double-blind randomized controlled trials (RCTs) comprising 239 MDD or BD patients with a major depressive episode. Active aiTBS overperformed sham stimulation in the study-defined response. This MA found preliminary evidence that active aiTBS resulted in a greater response in treating major depressive episodes in MDD or BD patients than sham stimulation.
我们旨在系统评估加速间歇 theta 爆发刺激（aiTBS）治疗重度抑郁症（MDD）或双相情感障碍（BD）患者的临床疗效和安全性。使用 Review Manager，Version 5.3 软件，采用随机效应模型分析主要和次要结局。这项荟萃分析（MA）确定了五项包括 239 例有重度抑郁发作的 MDD 或 BD 患者的双盲随机对照试验（RCT）。在研究定义的反应中，主动 aiTBS 优于假刺激。这项 MA 发现初步证据表明，与假刺激相比，主动 aiTBS 治疗 MDD 或 BD 患者重度抑郁发作的反应更大。
