Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
Chem Biol Interact. 2023 Aug 1;380:110553. doi: 10.1016/j.cbi.2023.110553. Epub 2023 May 16.
Both infectious and non-infectious diseases can share common molecular mechanisms, including oxidative stress and inflammation. External factors, such as bacterial or viral infections, excessive calorie intake, inadequate nutrients, or environmental factors, can cause metabolic disorders, resulting in an imbalance between free radical production and natural antioxidant systems. These factors may lead to the production of free radicals that can oxidize lipids, proteins, and nucleic acids, causing metabolic alterations that influence the pathogenesis of the disease. The relationship between oxidation and inflammation is crucial, as they both contribute to the development of cellular pathology. Paraoxonase 1 (PON1) is a vital enzyme in regulating these processes. PON1 is an enzyme that is bound to high-density lipoproteins and protects the organism against oxidative stress and toxic substances. It breaks down lipid peroxides in lipoproteins and cells, enhances the protection of high-density lipoproteins against different infectious agents, and is a critical component of the innate immune system. Impaired PON1 function can affect cellular homeostasis pathways and cause metabolically driven chronic inflammatory states. Therefore, understanding these relationships can help to improve treatments and identify new therapeutic targets. This review also examines the advantages and disadvantages of measuring serum PON1 levels in clinical settings, providing insight into the potential clinical use of this enzyme.
感染性和非传染性疾病都可以共享共同的分子机制，包括氧化应激和炎症。外部因素，如细菌或病毒感染、过度热量摄入、营养不足或环境因素，可能导致代谢紊乱，导致自由基产生和天然抗氧化系统之间的平衡失调。这些因素可能导致自由基的产生，自由基可以氧化脂质、蛋白质和核酸，导致影响疾病发病机制的代谢改变。氧化和炎症之间的关系至关重要，因为它们都有助于细胞病理学的发展。对氧磷酶 1（PON1）是调节这些过程的重要酶。PON1 是一种与高密度脂蛋白结合的酶，可保护机体免受氧化应激和有毒物质的侵害。它分解脂蛋白和细胞中的脂质过氧化物，增强高密度脂蛋白对不同病原体的保护作用，是先天免疫系统的关键组成部分。PON1 功能受损会影响细胞内稳态途径，并导致代谢驱动的慢性炎症状态。因此，了解这些关系有助于改善治疗方法并确定新的治疗靶点。本综述还探讨了在临床环境中测量血清 PON1 水平的优缺点，为该酶的潜在临床应用提供了见解。
