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基质对局部用糖皮质激素临床试验结果的影响。

Influence of the base on the results of clinical trials with topical corticosteroids.

作者信息

Vollum D I, Sparkes C G

出版信息

Dermatologica. 1979;158(4):293-8. doi: 10.1159/000250771.

DOI:10.1159/000250771
PMID:372027
Abstract

A comparative trial between betamethasone valerate and halcinonide has shown the former to be superior, thus contradicting the results from other trials. It is thought that the discrepancy is due to differences in the nature of the preparations used in the various studies. It is suggested that note is made of the base used in trials before final conclusions about the efficicacy of steroids are made.

摘要

一项关于戊酸倍他米松和哈西奈德的对比试验表明前者更具优势,这与其他试验结果相矛盾。据认为,差异是由于各项研究中所使用制剂的性质不同所致。建议在对类固醇药物的疗效得出最终结论之前,留意试验中所使用的基质。

相似文献

1
Influence of the base on the results of clinical trials with topical corticosteroids.基质对局部用糖皮质激素临床试验结果的影响。
Dermatologica. 1979;158(4):293-8. doi: 10.1159/000250771.
2
Once daily application of diflorasone diacetate ointment compared with betamethasone valerate ointment twice daily in patients with eczematous dermatoses.
J Int Med Res. 1982;10(6):423-5. doi: 10.1177/030006058201000607.
3
Systemic side-effects of three topical steroids in diseased skin.
Curr Med Res Opin. 1983;8(7):475-80. doi: 10.1185/03007998309109785.
4
Clinical trial comparing hydrocortisone 17-butyrate to betamethasone 17-valerate in a series of patients with eczematous skin diseases.
Dermatologica. 1976;152 Suppl 1:209-14. doi: 10.1159/000257891.
5
Halcinonide, a new topical anti-inflammatory steroid.哈西奈德,一种新型局部抗炎甾体。
J Int Med Res. 1976;4(1):34-6. doi: 10.1177/030006057600400104.
6
[Use of 0.3% diflucortolone valerate in the topical treatment of steroid-sensitive dermatitis].
G Ital Dermatol Venereol. 1986 Nov-Dec;121(6):LXXVII-LXXX.
7
Clinical comparison of halcinonide and betamethasone valerate in common dermatoses.哈西奈德与戊酸倍他米松治疗常见皮肤病的临床比较
Australas J Dermatol. 1975 Apr;16(1):17-9. doi: 10.1111/j.1440-0960.1975.tb00715.x.
8
Double-blind clinical comparisons of topical betamethasone valerate and betamethasone benzoate in the treatment of steroid-responsive dermatoses.
Br J Clin Pract. 1972 Sep;26(9):422-3.
9
Tibicorten and betamethasone valerate: a double-blind comparative study.特必可通与戊酸倍他米松:一项双盲对照研究。
J Int Med Res. 1977;5(5):338-45. doi: 10.1177/030006057700500509.
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Double-blind comparison of halcinonide and betamethasone valerate. Use with occlusive dressings in psoriasis treatment.卤米松与戊酸倍他米松的双盲比较。在银屑病治疗中与封闭敷料联合使用。
Arch Dermatol. 1975 Jun;111(6):731-3.

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