Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustín Tlaxiaca, Mexico.
Área Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma, Mexico.
Nat Prod Res. 2024 May;38(10):1759-1765. doi: 10.1080/14786419.2023.2214841. Epub 2023 May 19.
This study evaluated the possible use of a fraction of brewers' spent grain rich in arabinoxylans (BSG-AX) as an excipient that modifies the release of class III drugs (Biopharmaceutics Classification System), by determining the release profile of metformin hydrochloride (MH), in a water medium. The cumulative percentage of MH release showed the best linear fit when modeled with the cumulative distribution function (CDF) of the Weibull distribution ( = 0.993 ± 0.001). According to the Korsmeyer-Peppas model, the first stage of MH release is regulated by a super case-II transport mechanism controlled by the expansion and relaxation of BSG-AX. Finally, with the Hixson-Crowell model, a release rate () of 0.350 ± 0.026 was obtained ( = 0.996 ± 0.007). BSG-AX constitutes a suitable material for producing prolonged drug release vehicles; however, additional research is required to provide a better encapsulation of the active ingredients to ensure their optimal applicability and performance.
本研究评估了富含阿拉伯木聚糖的啤酒糟分馏物（BSG-AX）作为赋形剂的可能性，通过在水介质中测定盐酸二甲双胍（MH）的释放曲线来实现。当用威布尔分布的累积分布函数（CDF）对 MH 的累积释放百分比进行拟合时，得到最佳的线性拟合（ = 0.993 ± 0.001）。根据 Korsmeyer-Peppas 模型，MH 释放的第一阶段由超级二级运输机制控制，该机制由 BSG-AX 的膨胀和松弛来控制。最后，通过 Hixson-Crowell 模型，得到释放速率（）为 0.350 ± 0.026（ = 0.996 ± 0.007）。BSG-AX 是一种适合制备延长药物释放载体的材料；然而，需要进一步的研究来提供对活性成分的更好的包封，以确保其最佳的适用性和性能。
