Divisions of Infectious Diseases.
Pharmacy.
Hosp Pediatr. 2023 Jun 1;13(6):e140-e143. doi: 10.1542/hpeds.2022-006892.
To inform clinical decisions on the use of probiotics in a pediatric inpatient setting, we sought to determine the number of cases of Lactobacillus bacteremia as well as associated patient characteristics in a tertiary-care pediatric hospital over an 11-year period.
Cases of Lactobacillus bacteremia among admitted patients were identified through positive blood culture reports. The clinical chart for each case was reviewed for presenting symptoms and risk factors such as probiotic use, presence of a central venous catheter, immunocompromised state, impaired intestinal function, and age below 3 months. Concurrent total inpatient probiotic administration was assessed.
Over an 11-year period, 8 cases of Lactobacillus bacteremia were identified among 127 845 hospital admissions. All cases were associated with systemic signs of infection. Lactobacillus bacteremia patients most frequently had underlying impaired intestinal function and a central venous catheter. Three cases had a history of probiotic use. The peak number of annual cases did not coincide with the peak number of inpatients who received probiotics.
Lactobacillus bacteremia is uncommon and did not correlate with doses of probiotics-administered in the hospital. However, certain populations may be at higher risk and require extra consideration in clinical decision-making regarding use of probiotics.
为了在儿科住院环境下为临床决策提供信息，我们旨在确定在一家三级儿童医院 11 年间乳酸杆菌菌血症的病例数以及相关患者特征。
通过阳性血培养报告确定住院患者中的乳酸杆菌菌血症病例。回顾每个病例的临床图表，以确定其症状和危险因素，如益生菌使用、中心静脉导管存在、免疫功能低下、肠道功能受损以及年龄小于 3 个月。同时评估总住院益生菌的使用情况。
在 11 年间，在 127845 例住院患者中发现了 8 例乳酸杆菌菌血症。所有病例均与全身感染迹象有关。乳酸杆菌菌血症患者最常伴有潜在的肠道功能受损和中心静脉导管。有 3 例有使用益生菌的病史。每年病例的高峰期与接受益生菌治疗的住院患者的高峰期并不一致。
乳酸杆菌菌血症并不常见，与医院使用的益生菌剂量无关。然而，某些人群可能存在更高的风险，在临床决策中需要额外考虑使用益生菌。
