The rs7208505 Polymorphism and Differential Expression of the 2 Gene in the Prefrontal Cortex of Suicide Victims from the Mexican Population.

OBJECTIVE

The main aim of the current study was to investigate whether 2 gene expression in the postmortem brain of rs7208505 genotype are altered in suicide victims from a Mexican population.

METHODS

In this study, we report a genetic analysis of expression levels of the 2 gene in the prefrontal cortex of the postmortem brain of suicidal subjects ( = 22) compared to subjects who died of causes other than suicide ( = 22) in a Mexican population using RT-qPCR assays. Additionally, we genotyped the rs7208505 polymorphism in suicide victims ( = 98) and controls ( = 88) and we evaluate the association of genotypes for the SNP rs7208505 with expression level of 2.

RESULTS

The results showed that the expression of the 2 gene was significantly higher in suicide victims compared to control subjects ( = 0.044). Interestingly, we observed a greater proportion of allele A of the rs7208505 in suicide victims than controls. Even though there was no association between the SNP with suicide in the study population we found a significative association of the expression level from 2 with the allele A of the rs7208505 and suicide.

CONCLUSION

The evidence suggests that the expression of 2 in the prefrontal cortex may be a critical factor in the etiology of suicidal behavior.