Arch Suicide Res. 2024 Apr-Jun;28(2):674-685. doi: 10.1080/13811118.2023.2209155. Epub 2023 May 19.
The main aim of the current study was to investigate whether 2 gene expression in the postmortem brain of rs7208505 genotype are altered in suicide victims from a Mexican population.
In this study, we report a genetic analysis of expression levels of the 2 gene in the prefrontal cortex of the postmortem brain of suicidal subjects ( = 22) compared to subjects who died of causes other than suicide ( = 22) in a Mexican population using RT-qPCR assays. Additionally, we genotyped the rs7208505 polymorphism in suicide victims ( = 98) and controls ( = 88) and we evaluate the association of genotypes for the SNP rs7208505 with expression level of 2.
The results showed that the expression of the 2 gene was significantly higher in suicide victims compared to control subjects ( = 0.044). Interestingly, we observed a greater proportion of allele A of the rs7208505 in suicide victims than controls. Even though there was no association between the SNP with suicide in the study population we found a significative association of the expression level from 2 with the allele A of the rs7208505 and suicide.
The evidence suggests that the expression of 2 in the prefrontal cortex may be a critical factor in the etiology of suicidal behavior.
本研究的主要目的是探究 rs7208505 基因型在墨西哥自杀者死后大脑中的 2 基因表达是否发生改变。
本研究通过 RT-qPCR 检测，报告了在墨西哥人群中，对自杀者（n=22）和非自杀死亡者（n=22）的前额叶皮质中 2 基因表达水平的基因分析。此外，我们对自杀者（n=98）和对照组（n=88）进行了 rs7208505 多态性基因分型，并评估了 SNP rs7208505 与 2 表达水平的基因型之间的关联。
结果显示，与对照组相比，自杀者中 2 基因的表达显著升高（P=0.044）。有趣的是，我们观察到自杀者中 rs7208505 的等位基因 A 的比例高于对照组。尽管在研究人群中，该 SNP 与自杀之间没有关联，但我们发现 2 的表达水平与 rs7208505 的等位基因 A 与自杀之间存在显著关联。
证据表明，前额叶皮质中 2 的表达可能是自杀行为发病机制中的一个关键因素。
