Tsai Ching-Hua, Hsieh Ting-Min, Hsu Shiun-Yuan, Hsieh Ching-Hua
Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.
Risk Manag Healthc Policy. 2023 May 12;16:879-887. doi: 10.2147/RMHP.S409345. eCollection 2023.
The De Ritis ratio, which is the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT), has been suggested as a potential prognostic marker for various diseases. This study aimed to investigate the association between the De Ritis ratio and in-hospital mortality in adult trauma patients.
A total of 17,472 adult trauma patients hospitalized between January 1, 2009, and December 31, 2020, were allocated into groups according to the De Ritis ratio. The normal range of the De Ritis ratio was calculated from 3320 individuals in the National Taiwan Biobank. Statistical analyses were performed using SPSS software.
Patients with a De Ritis ratio >1.6 had a significantly higher in-hospital mortality rate (7.3% vs 1.5%, odds ratio 5.29; Q1-Q3 2.72-10.30; p < 0.001) and a 2.71-fold higher in-hospital mortality rate (Q1-Q3 1.24-5.92; p = 0.012), after adjusting for sex, age, comorbidities, consciousness level, and injury severity, than those with a De Ritis ratio within the reference values.
This study revealed that a De Ritis ratio >1.6 may serve as an early prognostic tool to identify adult trauma patients at high risk of in-hospital mortality.
德瑞蒂斯比值（De Ritis ratio）是天冬氨酸氨基转移酶（AST）与丙氨酸氨基转移酶（ALT）的比值，已被认为是多种疾病的潜在预后标志物。本研究旨在探讨德瑞蒂斯比值与成年创伤患者院内死亡率之间的关联。
将2009年1月1日至2020年12月31日期间住院的17472例成年创伤患者根据德瑞蒂斯比值分组。德瑞蒂斯比值的正常范围根据台湾生物银行的3320名个体计算得出。使用SPSS软件进行统计分析。
德瑞蒂斯比值>1.6的患者在调整性别、年龄、合并症、意识水平和损伤严重程度后，其院内死亡率显著更高（7.3%对1.5%，比值比5.29；四分位数间距2.72 - 10.30；p<0.001），且院内死亡率高出2.71倍（四分位数间距1.24 - 5.92；p = 0.012），高于德瑞蒂斯比值在参考值范围内的患者。
本研究表明，德瑞蒂斯比值>1.6可作为一种早期预后工具，用于识别有院内死亡高风险的成年创伤患者。
