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Successful Treatment of Refractory Ulcerative Proctitis in a Pediatric Patient Using Topical Tacrolimus.

作者信息

Nowacki Rélana, Vreugdenhil Anita, Kokke Freddy

机构信息

From the Maastricht University Medical Centre, Maastricht, The Netherlands.

出版信息

JPGN Rep. 2020 Sep 22;1(2):e012. doi: 10.1097/PG9.0000000000000012. eCollection 2020 Nov.

DOI:10.1097/PG9.0000000000000012
PMID:37206596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10191484/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a59/10191484/d499035be5b4/pg9-1-e012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a59/10191484/d499035be5b4/pg9-1-e012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a59/10191484/d499035be5b4/pg9-1-e012-g001.jpg

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Successful Treatment of Refractory Ulcerative Proctitis in a Pediatric Patient Using Topical Tacrolimus.局部使用他克莫司成功治疗一名儿科患者的难治性溃疡性直肠炎
JPGN Rep. 2020 Sep 22;1(2):e012. doi: 10.1097/PG9.0000000000000012. eCollection 2020 Nov.
2
Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis.他克莫司栓剂治疗难治性溃疡性直肠炎
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本文引用的文献

1
Current global trends in the incidence of pediatric-onset inflammatory bowel disease.当前儿科炎症性肠病发病的全球趋势。
World J Gastroenterol. 2018 Jul 7;24(25):2741-2763. doi: 10.3748/wjg.v24.i25.2741.
2
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis.直肠他克莫司治疗抵抗性溃疡性直肠炎的疗效。
Clin Gastroenterol Hepatol. 2017 Aug;15(8):1248-1255. doi: 10.1016/j.cgh.2017.02.027. Epub 2017 Mar 7.
3
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study.
溃疡性直肠炎是儿童发病 UC 的常见部位，并非小病：一项基于人群的研究。
Gut. 2017 Nov;66(11):1912-1917. doi: 10.1136/gutjnl-2016-311970. Epub 2016 Aug 3.
4
Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus.接受局部直肠他克莫司治疗的儿童中，他克莫司水平升高及与急性胃肠炎相关的急性肾损伤
Clin J Gastroenterol. 2014 Jun;7(3):238-42. doi: 10.1007/s12328-014-0482-6. Epub 2014 Apr 24.
5
Proximal disease extension and related predicting factors in ulcerative proctitis.溃疡性直肠炎的近端病变扩展及相关预测因素
Scand J Gastroenterol. 2014 Feb;49(2):177-83. doi: 10.3109/00365521.2013.867360. Epub 2013 Dec 11.
6
Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis.口服他克莫司（FK506）治疗住院的激素抵抗型溃疡性结肠炎患者的双盲、安慰剂对照试验。
Inflamm Bowel Dis. 2012 May;18(5):803-8. doi: 10.1002/ibd.21853. Epub 2011 Sep 1.
7
Local immune regulation of mucosal inflammation by tacrolimus.他克莫司对黏膜炎症的局部免疫调节。
Dig Dis Sci. 2010 Sep;55(9):2514-9. doi: 10.1007/s10620-009-1047-2. Epub 2009 Dec 1.
8
Local application of tacrolimus in distal colitis: feasible and safe.他克莫司在远端结肠炎中的局部应用：可行且安全。
Inflamm Bowel Dis. 2009 Feb;15(2):193-8. doi: 10.1002/ibd.20644.
9
Clinical outcome of ulcerative proctitis in children.儿童溃疡性直肠炎的临床结局
J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):149-52. doi: 10.1097/00005176-199708000-00004.