Furuta Tokiko, Arur Swathi
Department of Genetics, University of Texas MD Anderson Cancer Center.
MicroPubl Biol. 2023 May 2;2023. doi: 10.17912/micropub.biology.000820. eCollection 2023.
gene was first identified as the homolog of human SART3 ( S quamous cell carcinoma A ntigen R ecognized by T -cells 3). In humans, expression of SART3 is associated with squamous cell carcinoma, thus most of the studies focus on its potential role as a target of cancer immunotherapy (Shichijo et al. 1998; Yang et al. 1999). Furthermore, SART3 is also known as Tip110 (Liu et al. 2002; Whitmill et al. 2016) in the context of HIV virus host activation pathway. Despite these disease related studies, the molecular function of this protein was not revealed until the yeast homolog was identified as spliceosome U4/U6 snRNP recycling factor (Bell et al. 2002). The function of SART3 in development, however, remains unknown. Here we report that the mutant hermaphrodites exhibit a Mog ( M asculinization O f the G ermline) phenotype in adulthood suggesting that normally functions to regulate the switch from spermatogenic to oogenic gametic sex.
基因最初被鉴定为人类SART3（T细胞识别的鳞状细胞癌抗原3）的同源物。在人类中，SART3的表达与鳞状细胞癌相关，因此大多数研究集中于其作为癌症免疫治疗靶点的潜在作用（Shichijo等人，1998年；Yang等人，1999年）。此外，在HIV病毒宿主激活途径中，SART3也被称为Tip110（Liu等人，2002年；Whitmill等人，2016年）。尽管有这些与疾病相关的研究，但直到酵母同源物被鉴定为剪接体U4/U6 snRNP循环因子时，这种蛋白质的分子功能才得以揭示（Bell等人，2002年）。然而，SART3在发育中的功能仍然未知。在这里我们报告，该突变雌雄同体在成年期表现出Mog（生殖系雄性化）表型，这表明其正常功能是调节从生精配子到卵子生成配子性别的转换。
