Ngu Min Huang, Zakaria Rosnani, Mohd Zulkifli Maryam, Ab Rahman Rahiza
MBChB(Manchester), MAFP (Malaysia), ic FRACGP (Australia), Department of Family Medicine, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Email:
MD (UMS), Department of Family Medicine, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Malays Fam Physician. 2023 Apr 5;18:20. doi: 10.51866/cr.282. eCollection 2023.
Metformin-induced sexual dysfunction is rare in patients with diabetes mellitus. Herein, we present the case of a 57-year-old man newly diagnosed with type 2 diabetes mellitus who developed erectile dysfunction following treatment with metformin 500 mg BD. Prior to taking metformin, he had well-controlled hypertension, hyperlipidaemia and normal sexual function. Two weeks after beginning metformin therapy, he was diagnosed with erectile dysfunction after experiencing persistent difficulty achieving an erection. After discontinuation of metformin, his sexual function returned to normal. To determine whether sexual dysfunction is caused by metformin, we rechallenged the patient with metformin 500 mg BD. After 15 days, he became impotent again, confirming that metformin was the most likely cause of his sexual problem. Metformin was stopped, and his sexual function returned to normal after 3 weeks. The adverse reaction is 'probable' according to the World Health Organization-Uppsala Monitoring Centre.
二甲双胍诱发的性功能障碍在糖尿病患者中较为罕见。在此，我们报告一例57岁新诊断为2型糖尿病的男性患者，其在接受二甲双胍500毫克每日两次治疗后出现勃起功能障碍。在服用二甲双胍之前，他的高血压、高脂血症病情控制良好，性功能正常。开始二甲双胍治疗两周后，他在持续难以勃起后被诊断为勃起功能障碍。停用二甲双胍后，他的性功能恢复正常。为确定性功能障碍是否由二甲双胍引起，我们让该患者再次服用二甲双胍500毫克每日两次。15天后，他再次出现阳痿，证实二甲双胍很可能是其性功能问题的原因。停用二甲双胍，3周后他的性功能恢复正常。根据世界卫生组织-乌普萨拉监测中心的标准，该不良反应为“可能”。
