Kumamoto T, Fukuhara N, Miyatake T, Araki K, Takahashi Y, Araki S
Eur Neurol. 1986;25(4):269-77. doi: 10.1159/000116020.
Methyl mercury chloride (MMC, 10 mg/kg body weight/day) was subcutaneously injected into rats for 1 week. Animals were killed at 5 or 14 days (at the onset of clinical symptoms) after injection of MMC. Morphologically, most of the myelinated fibers in peripheral nerves showed axonal degeneration. Ganglion cells showed histopathological changes similar to those in previous reports. The cytoplasm of satellite cells stained dark with toluidine blue and was narrow, and sometimes showed focal disappearance of rough endoplasmic reticula, ribosomes or filaments. Autoradiography in the control rats showed that 3H-GABA was exclusively localized within the satellite cells and Schwann cell cytoplasm of the myelinated fibers and was not revealed within the ganglion cells. The number of silver grains markedly decreased in the satellite cells of the MMC-treated rats. 14C-GABA uptake by dorsal root ganglia also decreased to 75.0% of the control on the 5th day and to 49.2% on the 14th day. Therefore, MMC was found to inhibit greatly the GABA uptake into the satellite cells in the earlier stage of poisoning, and was considered to affect primarily the satellite cells and Schwann cells as well as the ganglion cells.
将氯化甲基汞（MMC，10毫克/千克体重/天）皮下注射到大鼠体内，持续1周。在注射MMC后的5天或14天（临床症状出现时）处死动物。形态学上，外周神经中的大多数有髓纤维显示轴突退变。神经节细胞呈现出与先前报道相似的组织病理学变化。卫星细胞的细胞质经甲苯胺蓝染色后颜色较深且狭窄，有时还显示粗面内质网、核糖体或细丝的局灶性消失。对照大鼠的放射自显影显示，3H-GABA仅定位于有髓纤维的卫星细胞和施万细胞胞质内，神经节细胞内未显示。MMC处理的大鼠卫星细胞中的银颗粒数量明显减少。背根神经节对14C-GABA的摄取在第5天降至对照的75.0%，在第14天降至49.2%。因此，发现MMC在中毒早期极大地抑制了卫星细胞对GABA的摄取，并且被认为主要影响卫星细胞、施万细胞以及神经节细胞。
