Ankara University Faculty of Medicine, Plastic Reconstructive and Aesthetic Surgery Department, Ankara.
Ankara University Faculty of Veterinary, Department of Veterinary Pathology, Ankara.
Injury. 2023 Jul;54(7):110791. doi: 10.1016/j.injury.2023.05.022. Epub 2023 May 6.
In present study, the effect of taurine on flap perfusion and viability was examined using the modified random pattern dorsal flap model (DFM).
Eighteen rats were included and divided equally (n=9) to taurine treatment and control groups in this study. Taurine treatments were given orally at a dose of 100 mg/kg/day. Taurine group received taurine, starting 3 days before the operation till the postoperative 3 day. Angiographic images were recorded when the flaps were sutured back and on postoperative 5 and 7 days. Necrosis calculations were made with all the images obtained by the digital camera and the indocyanine green angiography. Fluorescence intensity, fluorescence filling rate and flow rate of DFM were calculated by the SPY device and the SPY-Q software. All flaps were analyzed histopathologically, also.
Perioperative taurine treatment significantly reduced necrosis rates and increased the fluorescence density, the fluorescence filling rate and the flap filling rates in the DFM (p<0.05). Reduced amounts of necrosis, ulcer and polymorphonuclear leukocyte supported the beneficial effect of taurine histopathologically (p<0.05).
Taurine may be used as an effective medical agent for prophylactic treatment options in flap surgery.
在本研究中，使用改良随意皮瓣模型（DFM）研究牛磺酸对皮瓣灌注和存活的影响。
本研究纳入 18 只大鼠，平均分为（n=9）牛磺酸治疗组和对照组。牛磺酸治疗组以 100mg/kg/天的剂量口服牛磺酸。牛磺酸组在手术前 3 天开始接受牛磺酸治疗，直至术后第 3 天。在皮瓣缝合回原位时以及术后第 5 天和第 7 天记录血管造影图像。使用数码相机获得的所有图像计算坏死计算。通过 SPY 设备和 SPY-Q 软件计算 DFM 的荧光强度、荧光填充率和血流率。所有皮瓣均进行组织病理学分析。
围手术期牛磺酸治疗可显著降低皮瓣坏死率，增加 DFM 的荧光密度、荧光填充率和皮瓣填充率（p<0.05）。坏死、溃疡和多形核白细胞减少的量支持牛磺酸在组织病理学上的有益作用（p<0.05）。
牛磺酸可用作皮瓣手术预防性治疗的有效药物。
