在离体兔心脏中比较多巴胺、多巴酚丁胺、氨力农和异丙肾上腺素的心肌药效学。

Myocardial pharmacodynamics of dopamine, dobutamine, amrinone and isoprenaline compared in the isolated rabbit heart.

作者信息

Vigholt Sørensen E, Nielsen-Kudsk F

出版信息

Eur J Pharmacol. 1986 May 13;124(1-2):51-7. doi: 10.1016/0014-2999(86)90123-8.

PMID:3720844

Abstract

The isolated spontaneously beating rabbit heart was used for comparing the myocardial effects of isoprenaline, dobutamine, dopamine and amrinone. Both isoprenaline and dobutamine produced a progressive concentration-dependent increase in contractility from 100% to a maximum of about 200% (pD2 7.81 and 7.01, respectively) as measured by the increase in isotonic contraction rate. The simultaneous augmentations in contraction amplitude reached maxima of about 127 and 143% (pD2 7.83 and 7.05) for each of the drugs and the heart frequency rose to 202 and 162% (pD2 7.80 and 6.63), respectively. The accompanying oxygen consumption increased from 100 to 194% (pD2 7.70) for isoprenaline and to only 177% (pD2 6.36) for dobutamine. Coronary flow rate rose to 153 and 134%, respectively. Dopamine increased the contraction rate to 181% (pD2 6.26), contraction amplitude to about 122% (pD2 6.25) and heart rate to 162% (pD2, 5.85), while oxygen consumption rose to a maximum of 202% (pD2 5.69). Coronary flow rate rose to 156%. In contrast amrinone produced an unexpected slowly progressing decrease in contraction rate and contraction amplitude to about 66% (pD2 4.45 and 4.01, respectively). Oxygen consumption increased to 159% (pD2 4.10) and coronary flow rate to 210%. The positive inotropic effect of dobutamine thus equalled that of isoprenaline but with a distinct lower concomitant increase in heart frequency and oxygen consumption which may reflect a better myocardial efficiency during the action of dobutamine.

摘要

采用离体自发搏动的兔心脏比较异丙肾上腺素、多巴酚丁胺、多巴胺和氨力农对心肌的作用。通过等张收缩速率的增加来衡量，异丙肾上腺素和多巴酚丁胺均可使收缩性呈浓度依赖性逐渐增加，从100%增至最大值约200%（pD2分别为7.81和7.01）。两种药物同时使收缩幅度的增加分别达到最大值约127%和143%（pD2分别为7.83和7.05），心率分别升至202%和162%（pD2分别为7.80和6.63）。伴随的耗氧量，异丙肾上腺素从100%增至194%（pD2 7.70），多巴酚丁胺仅增至177%（pD2 6.36）。冠脉血流量分别升至153%和134%。多巴胺使收缩速率增至181%（pD2 6.26），收缩幅度增至约122%（pD2 6.25），心率增至162%（pD2 5.85），而耗氧量最大升至202%（pD2 5.69）。冠脉血流量升至156%。相比之下，氨力农使收缩速率和收缩幅度意外地缓慢下降至约66%（pD2分别为4.45和4.01）。耗氧量增至159%（pD2 4.10），冠脉血流量增至210%。因此，多巴酚丁胺的正性肌力作用与异丙肾上腺素相当，但伴随的心率和耗氧量增加明显较低，这可能反映出多巴酚丁胺作用期间心肌效率更高。