Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Program of Basic Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Dev Growth Differ. 2023 Aug;65(6):337-347. doi: 10.1111/dgd.12867. Epub 2023 Jun 14.
Cell behavior changes in response to multiple stimuli, such as growth factors, nutrients, and cell density. The mechanistic target of the rapamycin (mTOR) pathway is activated by growth factors and nutrient stimuli to regulate cell growth and autophagy, whereas the Hippo pathway has negative effects on cell proliferation and tissue growth in response to cell density, DNA damage, and hormonal signals. These two signaling pathways must be precisely regulated and integrated for proper cell behavior. This integrative mechanism is not completely understood; nevertheless, recent studies have suggested that components of the mTOR and Hippo pathways interact with each other. Herein, as per contemporary knowledge, we review the molecular mechanisms of the interaction between the mTOR and Hippo pathways in mammals and Drosophila. Moreover, we discuss the advantage of this interaction in terms of tissue growth and nutrient consumption.
细胞行为会对多种刺激（如生长因子、营养物质和细胞密度）作出响应而发生改变。雷帕霉素（mTOR）途径的机械靶点受生长因子和营养刺激激活，从而调节细胞生长和自噬，而 Hippo 途径则对细胞密度、DNA 损伤和激素信号作出响应，对细胞增殖和组织生长产生负向影响。这两种信号通路必须进行精确的调节和整合，以保证细胞行为的正常。尽管目前对这一整合机制还不完全了解，但最近的研究表明，mTOR 和 Hippo 通路的成分相互作用。在此，根据现有知识，我们综述了哺乳动物和果蝇中 mTOR 和 Hippo 通路相互作用的分子机制。此外，我们还讨论了这种相互作用在组织生长和营养消耗方面的优势。
