Savina M D
Farmakol Toksikol. 1986 May-Jun;49(3):47-50.
Hydrochloride beta-(N,N-diethylamino)ethylamide of fusaric acid (DAEA) exerted an antiarrhythmic activity in adrenaline-induced arrhythmia in rats. DAEA single pretreatment in doses of 1-5 mg/kg prevented the disorders of rhythm and conductivity in most animals. A pronounced antiarrhythmic effect was manifest at doses of 2 and 4 mg/kg of DAEA. The comparison of efficacy of DAEA, obzidan and atenolol showed that atenolol exhibited only a low antiarrhythmic activity, DAEA prevented the development of arrhythmia in 50% of animals in a dose of 1.7 mg/kg (1/42 of LD50) and obzidan--1 mg/kg (1/40 of LD50), respectively. The antiarrhythmic effect of DAEA was not followed by marked suppression of cardiac conductivity.
富马酸β-（N，N-二乙氨基）乙酰胺盐酸盐（DAEA）对大鼠肾上腺素诱发的心律失常具有抗心律失常活性。剂量为1-5mg/kg的DAEA单次预处理可预防大多数动物的节律和传导紊乱。在DAEA剂量为2和4mg/kg时，表现出明显的抗心律失常作用。DAEA、奥齐丹和阿替洛尔疗效比较表明，阿替洛尔仅表现出低抗心律失常活性，DAEA剂量为1.7mg/kg（LD50的1/42）时可预防50%动物发生心律失常，奥齐丹——剂量为1mg/kg（LD50的1/40）时可预防50%动物发生心律失常。DAEA的抗心律失常作用并未伴随明显的心脏传导抑制。
