[Comparative effectiveness of the beta-(N,N-diethylamino)ethylamide hydrochloride of fusaric acid, obzidan and atenolol in experimental adrenaline-induced cardiac arrhythmia].

Hydrochloride beta-(N,N-diethylamino)ethylamide of fusaric acid (DAEA) exerted an antiarrhythmic activity in adrenaline-induced arrhythmia in rats. DAEA single pretreatment in doses of 1-5 mg/kg prevented the disorders of rhythm and conductivity in most animals. A pronounced antiarrhythmic effect was manifest at doses of 2 and 4 mg/kg of DAEA. The comparison of efficacy of DAEA, obzidan and atenolol showed that atenolol exhibited only a low antiarrhythmic activity, DAEA prevented the development of arrhythmia in 50% of animals in a dose of 1.7 mg/kg (1/42 of LD50) and obzidan--1 mg/kg (1/40 of LD50), respectively. The antiarrhythmic effect of DAEA was not followed by marked suppression of cardiac conductivity.