[红景天提取物及对羟基苯乙醇在实验性心律失常模型中的抗心律失常作用]
[The anti-arrhythmia action of an extract of Rhodiola rosea and of n-tyrosol in models of experimental arrhythmias].
作者信息
Maĭmeskulova L A, Maslov L N
机构信息
Department of Experimental Cardiology, Russian Academy of Medical Sciences, Tomsk Research Center, Russia.
出版信息
Eksp Klin Farmakol. 1998 Mar-Apr;61(2):37-40.
PMID:9621172
Abstract
A daily 8-day course of Rhodiolae fluidum extract (1 ml/kg; ED50 = 0.43 ml/kg)--a preparation from the group of adaptogens caused a marked preventive antiarrhythmic effect on models of adrenaline and CaCl2-induced, but not acontine, arrhythmias. Aglycone--n-tyrosol demonstrated a lower antiarrhythmic activity (ED50 = 16 mg/kg) than that of Rhodiola extract.
摘要
红景天流浸膏（1毫升/千克；半数有效量=0.43毫升/千克）——一种适应原类制剂，连续8天每日给药，对肾上腺素和氯化钙诱导的心律失常模型产生了显著的预防性抗心律失常作用，但对乌头碱诱导的心律失常无效。苷元——对香豆酸的抗心律失常活性（半数有效量=16毫克/千克）低于红景天提取物。
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